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Planta Med 1978; 33(1): 57-62
DOI: 10.1055/s-0028-1097359

© Georg Thieme Verlag Stuttgart · New York

Preparation of β–Methyldigoxin by Hydroxylation of β–Methyldigitoxin in Fermenter Cultures of Digitalis lanata

M. Heins1 , J. Wahl1 , H. Leren2 , F. Kaiser2 , E. Reinhard1
  • 1Lehrstuhl für Pharmazeutische Biologie, Universität Tübingen.
  • 2Boehringer Mannheim, Chemische Forschung, Mannheim, Federal Republic of Germany.
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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

β–Methyldigitoxin was hydroxylated to β–methyldigoxin by cell cultures of Digitalis lanata in airlift bioreactors. β–Methyldigoxin could be recovered and crystallized.

Key Word Index

Digitalis lanata - Plant Cell Culture - Cardiac Glycosides - Biotransformation - 12–β–Hydroxylation - Fermentation