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Planta Med 1978; 34(7): 264-273
DOI: 10.1055/s-0028-1097449
DOI: 10.1055/s-0028-1097449
Research Articles
© Georg Thieme Verlag Stuttgart · New York
New Indole Alkaloids of Strychnos dale and Strychnos elaeocarpa
1 The name kribine was chosen because both S. dale and S. elaeocarpa were collected in Kribi, Cameroun.Further Information
Publication History
Publication Date:
13 January 2009 (online)
Abstract
The nonpolar fractions of the tertiary alkaloid extracts of Strychnos dale De Wild, and Strychnos elaeocarpa Gilg ex Leeuwenberg show strong convulsant activity, of both clonic and tonic type. The polar fractions of the extracts have a muscle–relaxant effect.
The same five alkaloids have been isolated from each of the nonpolar fractions of the two Strychnos species : Akagerine and four new indole alkaloids, 17–O–methyl–akagerine, kribine1, 21–O–methyl–kribine and epi–21–O–methyl–kribine.
Key Word Index
Strychnos dale - Strychnos elaeocarpa - Loganiaceae - Akagerine - 17–O–methyl–akagerine - Kribine - 21–O–methyl–kribine - epi–21–O–methyl–kribine - indole alkaloids - 13C–NMR - Pharmacology