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Planta Med 1975; 28(5): 32-36
DOI: 10.1055/s-0028-1097826
© Georg Thieme Verlag Stuttgart · New York

ANTITUMOUR EFFECTS AGAINST SARCOMA 180 ASCITES OF FRACTIONS OF ANNONA SENEGALENSIS

J. I. Durodola
  • Department of Surgery (Oncology Unit), University of Ibadan, Ibadan, NIGERIA
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Publication Date:
14 January 2009 (online)

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Abstract

A constituent of the rootbark of Annona senegalensis, used by Nigerian traditional healers to treat cancer, was isolated, purified and its antineoplastic activity measured against sarcoma 180 ascites tumour cells. At the optimal daily dose of 100 mg/kg intraperitoneally (i.p.), the active material, designated C/M2 was a potent antitumour agent showing 100 % tumour inhibition and prolongation of survival for 60 days or more with no toxicity to the host. There is a wide margin of safety by the drug, the effective daily dose (ED100) is 100 mg/kg while 200 mg/kg is not toxic to the test mice. C/Ms, another component of the mixture had no antitumour activity, even at a very toxic dose-level.