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Planta Med 1974; 26(6): 150-154
DOI: 10.1055/s-0028-1097982
© Georg Thieme Verlag Stuttgart · New York

OCCURRENCE OF INGENOL IN ELAEOPHORBIA SPECIES

A. D. Kinghorn, F. J. Evans
  • Department of Pharmacognosy, The School of Pharmacy (University of London) 29/39, Brunswick Square, London, WC1N 1AX
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Publication Date:
14 January 2009 (online)

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Abstract

The latex of two species of the genus Elaeophorbia (Vam. Euphorbiaceae) were shown by means of biological analysis involving the mice ear assay to be highly irritant. The irritant dose 50 % (ID SO) was similar to several latices from Euphorbia species, being within the range 8.4 to 17.0 fig per 5 μl of acetone extract. By means of TLC, GLC, mass-spectrometry, circular dichroism and nuclear magnetic resonance spectroscopy, the parent alcohol of the irritant ester fraction was identiefied as the diterpene ingenol.