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Planta Med 1972; 22(8): 412-417
DOI: 10.1055/s-0028-1099627
© Georg Thieme Verlag Stuttgart · New York

BIOLOGICAL ACTIVITY OF PHYTOESTROGENS

VI Fractionation of Plasma Proteins Associated with β–Sitosterol TreatmentR. R. Hassanein, S. A. Elmougy, M. I. Elghamry
  • Faculty of Veterinary Medicine, Ein Shams University Zagazig, Egypt
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Publikationsdatum:
15. Januar 2009 (online)

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Abstract

Under our conditions, the electrophoretic pattern of plasma obtained from ovariectomized mice showed 4 distinct fractions: albumin, alpha–globulin, beta–globulin + fibrinogen and gamma–globulin. Administration of β–sitosterol induced the following changes in their percentage composition:

  1. All the applied doses of β–sitosterol induced a significant increase in the albumin content of plasma.

  2. Alpha–globulin remained unchangeable in all the treated groups except at the higher dosage level (75 and 100 (μg) when it was significantly increased.

  3. The beta–fibrinogen complex underwent a significant increase after subcutaneous injection of 25, 50, 75 and 100 μg daily.

  4. Lower doses were uneffective on gamma–globulin which was significantly reduced by increasing the phytoestrogen to 50, 75 and 100 μg daily.

  5. Colorimetric estimation of total proteins in the plasma of treated animals showed no response to β–sitosterol application.