Pharmacopsychiatry 2009; 42(3): 85-88
DOI: 10.1055/s-0028-1103294
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Clinical Benefits and Cost Effectiveness of Vagus Nerve Stimulation in a Long-term Treatment of Patients with Major Depression

W. Sperling 1 [*] , U. Reulbach 1 [*] , J. Kornhuber 1
  • 1Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany
Weitere Informationen

Publikationsverlauf

received 11.06.2008 revised 15.10.2008

accepted 20.10.2008

Publikationsdatum:
18. Mai 2009 (online)

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Abstract

Background: To evaluate clinical aspects and cost effectiveness of the treatment with vagus nerve stimulation (VNS), a group of 9 VNS-implanted patients and 9 age- and sex-matched patients suffering from treatment-resistant depression were included in a prospective study.

Methods: The psychopathological ratings over 12 months as well as socio-economic data on the duration of hospitalisation, frequency of outpatient treatment, and subsequent drug treatment were compared with the pre-implantation period.

Results: Compared with baseline values in the HAMD scale (mean 23.7; SD 2.4), there was a significant (t=14.5; df=8; p<0.001) improvement in symptoms after 12 months’ stimulation (mean 10.2; SD 2.4). The duration of hospitalisation dropped on average by 20 days in the first post-implantation year, the treatment frequency from 33 to 14 visits, and drug treatment from 4 to an average of 3 psychotropic drugs.

Conclusion: In addition to an improvement in clinical symptoms, the VNS method might enable an amortisation of costs.

References

1 Each author contributed equally to this work.

Correspondence

W. SperlingMD 

Department of Psychiatry and Psychotherapy

University Hospital of Erlangen

Schwabachanlage 6

91054 Erlangen

Germany

Telefon: +49/9131/853 61 94

Fax: +49/9131/853 60 02

eMail: Wolfgang.Sperling@uk-erlangen.de