An Unusual Presentation of Infantile Fibrosarcoma in a Male Newborn

ABSTRACT

We describe a 10-day-old male presenting with drop foot and immobility in his right leg; no abnormality in physical examination had been found upon delivery or discharge. Magnetic resonance imaging showed a pelvic mass with an extension to the great sciatic foramen. Fine-needle aspiration biopsy revealed congenital infantile fibrosarcoma. He was started on vincristine, actinomycin-D, cyclophosphamide chemotherapy. However, he died soon after the second cycle due to veno-occlusive disease of the liver. Differential diagnosis of drop foot and immobility in lower extremity must include infiltrating neoplasms in pelvis.

KEYWORDS

Infantile fibrosarcoma - pelvis - drop foot - immobility - leg

REFERENCES

• 1 Soule E H, Pritchard D J. Fibrosarcoma in infants and children: a review of 110 cases.  Cancer. 1977;  40 1711-1721
• 2 Chung E B, Enzinger F M. Infantile fibrosarcoma.  Cancer. 1976;  38 729-739
• 3 Lee M J, Cairns R A, Munk P L, Poon P Y. Congenital-infantile fibrosarcoma: magnetic resonance imaging findings.  Can Assoc Radiol J. 1996;  47 121-125
• 4 Cofer B R, Vescio P J, Wiener E S. Infantile fibrosarcoma: complete excision is the appropriate treatment.  Ann Surg Oncol. 1996;  3 159-161
• 5 Nonaka D, Sun C C. Congenital fibrosarcoma with metastasis in a fetus.  Pediatr Dev Pathol. 2004;  7 187-191
• 6 Fisher C. Myofibroblastic malignancies.  Adv Anat Pathol. 2004;  11 190-201
• 7 Coffin C M, Dehner L P. Fibroblastic-myofibroblastic tumors in children and adolescents: a clinicopathologic study of 108 examples in 103 patients.  Pediatr Pathol. 1991;  11 569-588
• 8 Stout A P. Fibrosarcoma in infants and children.  Cancer. 1962;  15 1028-1040
• 9 Yalcin B, Leblebicioğlu G, Güler E et al.. Congenital infantile fibrosarcoma of the thigh in a newborn.  Tumori. 2001;  87 436-438
• 10 Shetty A K, Yu L C, Gardner R V, Warrier R P. Role of chemotherapy in the treatment of infantile fibrosarcoma.  Med Pediatr Oncol. 1999;  33 425-427
• 11 Arndt C, Hawkins D, Anderson J R et al.. Age is a risk factor for chemotherapy-induced hepatopathy with vincristine, dactinomycin and cyclophosphamide.  J Clin Oncol. 2004;  22 1894-1901