Primäre oder sekundäre Prophylaxe der AMD mit Anthocyanen?

Zusammenfassung

Anthocyanzubereitungen aus Heidelbeeren haben in den vergangenen 2 Jahren in der Schweiz bei Patienten mit altersabhängiger Makuladegeneration (AMD) eine breite Anwendung zum Zweck der primären und sekundären Prophylaxe gefunden. Humane Studienergebnisse zur Analyse von Sicherheit und Effektivität bei AMD-Patienten liegen bislang nicht vor. Der aktuelle Stand der wissenschaftlichen Literatur zum Problemkreis einer Einnahme von Anthocyanen wird in diesem Review dargestellt.

Abstract

Bilberry extracts containing anthocyanins have become rather popular within the last 2 years among patients with age-related macular degeneration (AMD) in Switzerland as a medication for primary or secondary prophylaxis. So far human study results concerning safety and efficacy in AMD patients are not available. The present state of the scientific literature concerning the use of anthocyanins with relation to AMD will be analysed in this review.

Schlüsselwörter

AMD - altersabhängige Makuladegeneration - Heidelbeeren - Anthocyane

Key words

AMD - age-related macular degeneration - bilberry - anthocyanins - anthocyans

Literatur

• 1 Alfieri R, Sole P. Influence des anthocyanosides administres par voie orperlinguale sur l’adapto-electroretinogramme (AERG) en lumière rouge chez l’homme.  Soc Biol Clermont-Ferrand. 1966;  160 1590-1593
• 2 Belleoud L, Leluan D, Boyer Y. Etudes des effets des glucosides d’anthocyan sur la vision nocturne des controleurs d’approche d’aerodrome.  Rev Med Aeronaut Spat. 1966;  18 45-50
• 3 Canter P H, Ernst E. Anthocyanosides of Vaccinium myrtillius (Bilberry) for night vision – a systematic review of placebo-controlled trials.  Surv Ophthalmol. 2004;  49 38-50
• 4 Cavallacci G, Marconcini C. Valutazioni sperimentali delle modificazione indotte dagli antocianosidi sull ERG.  Minerva Oftalmol. 1979;  21 339
• 5 Chong E W, Wong T Y, Kreis A J. et al . Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis.  BMJ. 2007;  335 755-763
• 6 Clifford M N. Anthocyans – nature, occurrence and dietary burden.  J Sci Food Agric. 2000;  80 1063-1072
• 7 Ferretti C, Magistretti M J, Robotti A. et al . Vaccinium myrtillus antocyanosides are inhibitors of cAMP and cGMP phosphodiesterase.  Pharmacol Res Commun. 1988;  20 150
• 8 Fursova A Z, Gesarevich O G, Gonchar A M. et al . Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senescence-accelerated OXYS rats.  Adv Gerontol. 2005;  16 76-79
• 9 Ishchenko A, Sinitsyna O, Krysanova Z. et al . Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil- DNA glycosylase activities in liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats.  Med Sci Monit. 2003;  9 16-24
• 10 Jang Y P, Zhou J, Nakanishi K. et al . Anthocyanins protect against A 2E photooxidation and membrane permeabilization in retinal pigment epithelial cells.  Photochem Photobiol. 2005;  81 529-536
• 11 Jayle G E, Aubert L. Action des glucosides d’anthocyanes sur la vision scotopique et mesopique du suject normal.  Therapie. 1964;  19 171-175
• 12 Kalt W, Blumberg J B, McDonald J E. et al . Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs.  J Agric Food Chem. 2008;  56 705-712
• 13 Kiser A, Dagneli G. Reported effects of non-traditional treatments and complementary and alternative medicine by retinitis pigmentosa.  Clin Exp Optom. 2008;  91 166-176
• 14 Kong J M, Chia L S, Goh N K. et al . Analysis and biological activities of anthocyanins.  Phytochemistry. 2003;  64 923-933
• 15 Lazzé M C, Savio M, Pizzala R. et al . Anthocyanes induce cell cycle pertubations and apoptosis in different human cell lines.  Carcinogenesis. 2004;  25 1427-1433
• 16 Martinelle E M, Baj A, Bombardelli E. Computer aided evaluation of liquid-chromatographic profiles for anthocyanins in Vaccinium myrtillus.  Anal Chim Acta. 1995;  191 275
• 17 Matsumoto H, Nakamura Y, Tachibanaki S. et al . Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin.  J Agric Food Chem. 2003;  51 3560-3563
• 18 Milburry P E, Graf B, Curran-Celentano M. et al . Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathinone S-transferase-pi expression in ARPE-19 cells.  Invest Ophthalmol Vis Sci. 2007;  48 2343-2349
• 19 Muth E, Lauerent J, Jasper P. The effect of bilberry nutritional supplementation on night vision acuity and contrast sensitivity.  Altern Med Rev. 2000;  5 164-173
• 20 Sparrow J R, Vollmer-Snarr H R, Zhou J. et al . A2E-epoxides damage DNA in retinal pigment epithelial cells.  J Biol Chem. 2003;  20 18 207-18 213
• 21 The New Encyclopedia Britannica. Chicago; Encyclopedia Britannica Inc 1998 32. Edition
• 22 Virmaux N, Bizec J C, Nullans G. et al . Modulation of rod cyclic GMP-phosphodiesterase activity by anthocyanin derivatives.  Biochem Soc Trans. 1990;  18 686-687
• 23 Wikipedia .Anthocyane. 26.09.2008 http://www.wikipedia.org/