Biologische Korrelate präfrontal aktivierender und temporoparietal inhibierender Behandlung mit repetitiver transkranieller Magnetstimulation (rTMS)

A. Mobascher; M. Arends; G. W. Eschweiler; J. Brinkmeyer; M. W. Agelink; J. Kornischka; G. Winterer; J. Cordes

doi:10.1055/s-0028-1109494

Fortschritte der Neurologie · Psychiatrie, Table of Contents

Fortschr Neurol Psychiatr 2009; 77(8): 432-443
DOI: 10.1055/s-0028-1109494

Übersicht

Biologische Korrelate präfrontal aktivierender und temporoparietal inhibierender Behandlung mit repetitiver transkranieller Magnetstimulation (rTMS)

Biological Correlates of Prefrontal Activating and Temporoparietal Inhibiting Treatment with Repetitive Transcranial Magnetic Stimulation (rTMS)A. Mobascher^1, ² , M. Arends¹ , G. W. Eschweiler³ , J. Brinkmeyer^1, ² , M. W. Agelink⁴ , J. Kornischka⁴ , G. Winterer^1, ² , J. Cordes¹

¹Klinik und Poliklinik für Psychiatrie und Psychotherapie, Heinrich-Heine-Universität Düsseldorf
²Institut für Medizin, Forschungszentrum Jülich
³Universitätsklinik für Psychiatrie und Psychotherapie, Tübingen
⁴Klinik für Psychiatrie, Psychotherapie and Psychosomatik, Herford

Abstract

Zusammenfassung

Die repetitive transkranielle Magnetstimulation (rTMS) ermöglicht es, auf nicht invasive Weise die kortikale Aktivität zu verändern. Durch hochfrequente rTMS sind überwiegend aktivierende und durch niederfrequente rTMS inhibierende Effekte möglich. Neben ihrer Anwendung als Forschungsinstrument und diagnostisches Werkzeug in der Neurologie ergeben sich potenzielle therapeutische Anwendungsgebiete in der Psychiatrie, und zwar insbesondere in der Behandlung von Krankheiten bzw. Symptomen, die mit regionalen kortikalen Aktivitätsveränderungen einhergehen. Derzeit wird die rTMS u. a. in der Behandlung der Depression und der schizophrenen Negativ-Symptomatik evaluiert. Bei beiden Syndromen könnte eine Hypofrontalität bzw. eine frontolimbische Dysbalance durch eine aktivierende rTMS „korrigiert” bzw. therapiert werden. Umgekehrt besteht beim Tinnitus und bei akustischen Halluzinationen eine Hyperaktivität temporoparietaler Areale. Hier wird der therapeutische Nutzen einer niederfrequenten inhibierenden rTMS untersucht. Neben der direkten Modulation der stimulierten kortikalen Region sind weitere biologische Effekte der rTMS beschrieben, die für die therapeutische Wirkung bedeutsam sein könnten. Hierzu zählen Veränderung der Aktivität in krankheitsrelevanten kortiko-kortikalen Schaltkreisen, Modulation der Ausschüttung biogener Amine aus subkortikalen Kerngebieten und schließlich neuroendokrine Effekte. In dieser Übersicht wird der aktuelle Kenntnisstand über die therapeutisch relevanten biologischen Effekte der rTMS dargestellt. Ein besseres Verständnis der neurophysiologischen Grundlagen der rTMS und der zu behandelnden psychiatrischen Störungen sollte zu optimierten Stimulationsprotokollen und besser definierten Behandlungsindikationen führen.

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a tool that enables clinicians and neuroscientists to modulate cortical activity in a non-invasive way. High-frequency rTMS has predominantly an activating effect on the stimulated brain region while low-frequency rTMS has an inhibitory effect. In addition to its usefulness as a research tool and in neurological diagnostics, rTMS may prove useful as a therapeutic option in psychiatry, especially in disorders that are associated with regional changes in cortical activity. For instance, rTMS is under current investigation in the treatment of depression and negative symptoms of schizophrenia. A hypofrontality or a fronto-limbic imbalance associated with both syndromes could be corrected by activating, high frequency rTMS. Conversely, a regional hyperactivity in the temporo-parietal cortex has been described in subjects suffering from auditory hallucinations and tinnitus. Low frequency, inhibitory rTMS is currently evaluated as a therapeutic option in these subjects. In addition to the effects on the directly stimulated brain area, other biological effects of rTMS may exert a beneficial influence on brain function. Amongst these are a modulation of cortico-cortical circuits (e. g. fronto-cingular and fronto-parietotemporal circuits), effects on monoaminergic neuromodulation and neuroendocrine effects. The current knowledge about the therapeutically relevant neurophysiological and neuroendocrine effects of rTMS are reviewed. An improved understanding of the neurophysiological basis of the therapeutic effects of rTMS and of the pathophysiology underlying neuropsychiatric diseases may lead to optimized therapeutic rTMS applications and new clinical indications for rTMS.

Schlüsselwörter

rTMS - Schizophrenie - Tinnitus - Depression - Hypofrontalität

Key words

rTMS - schizophrenia - tinnitus - depression - hypofrontality

Full Text

References

Literatur

1 Gershon A A, Dannon P N, Grunhaus L. Transcranial magnetic stimulation in the treatment of depression. Am J Psychiatry. 2003; 160 835-845
2 Martin J LR, Barbanoj M J, Schlaepfer T E. et al . Repetitive transcranial magnetic stimulation for the treatment of depression. Br J Psychiatry. 2003; 182 480-491
3 Mitchell P B, Loo C K. Transcranial magnetic stimulation for depression. Aust N Z J Psychiatry. 2006; 40 406-413
4 Fregni F, Marcolin M A, Myczkowski M. et al . Predictors of antidepressant response in clinical trials of transcranial magnetic stimulation. Int J Neuropsychopharmacol. 2006; 9 641-654
5 Herwig U, Fallgatter A J, Höppner J. et al . Antidepressant effects of augmentative transcranial magnetic stimulation: randomised multicentre trial. Br J Psych. 2007; 191 441-448
6 Cordes J, Arends M, Mobascher A. et al . Potential clinical targets of repetitive transcranial magnetic stimulation (rTMS) treatment in schizophrenia. Neuropsychobiology. 2006; 54 87-99
7 Saba G, Schurhoff F, Leboyer M. Therapeutic and neurophysiologic aspects of transcranial magnetic stimulation in schizophrenia. Neurophysiol Clin. 2006; 36 185-194
8 Londero A, Langguth B, De Ridder D. et al . Repetitive transcranial magnetic stimulation (rTMS): a new therapeutic approach in subjective tinnitus?. Neurophysiol Clin. 2006; 36 145-155
9 Kleinjung T, Steffens T, Langguth B. et al . Treatment of chronic tinnitus with neuronavigated repetitive transcranial magnetic stimulation (rTMS). HNO. 2006; 54 439-444
10 Bench C J, Friston K J, Brown R G. et al . Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychol Med. 1993; 23 579-590
11 Dierks T, Linden D E, Jandl M. et al . Activation of Heschl’s gyrus during auditory hallucinations. Neuron. 1999; 22 616-621
12 Shergill S S, Brammer M J, Williams S C. et al . Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Arch Gen Psychiatry. 2000; 57 1033-1038
13 Linden D E. Akustische Halluzinationen und funktionelle Bildgebung. Fortschr Neurol Psych. 2008; 76 (Suppl 1) S33-S39
14 Kähkönen S, Komssi S, Wilenius J. et al . Prefrontal TMS produces smaller EEG responses than motor-cortex TMS: implications for rTMS treatment in depression. Psychopharmacology. 2005; 18 16-20
15 Komssi S, Kähkönen S. The novelty of the combined use of electroencephalography and transcranial magnetic stimulation for neuroscience research. Brain Res Rev. 2006; 52 183-192
16 Van Der Werf Y D, Paus T. The neural response to transcranial magnetic stimulation of the human motor cortex. Intracortical and cortico-cortical contributions. Exp Brain Res. 2006; 175 231-245
17 Pascual-Leone A, Valls-Sole J, Wassermann E M. et al . Responses to rapid- rate transcranial magnetic stimulation of the human motor cortex. Brain. 1994; 117 847-858
18 Speer A M, Kimbrell T A, Wassermann E M. et al . Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol Psychiatry. 2000; 48 1133-1141
19 Lang N, Harms J, Weyh T. et al . Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability. Clin Neurophysiol. 2006; 117 2292-2301
20 Padberg F, Zwanzger P, Keck M E. et al . Repetitive transcranial magnetic stimulation (rTMS) in major depression: relation between efficacy and stimulation intensity. Neuropsychopharmacology. 2002; 27 638-645
21 Hoffman R E, Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. Am J Psychiatry. 2004; 159 1093-1102
22 Simons W, Dierick M. Transcranial magnetic stimulation as a therapeutic tool in psychiatry. World J Biol Psychiatry. 2005; 6 6-25
23 Esser S K, Huber R, Massimi M. et al . A direct demonstration of cortical LTP in humans: A combined TMS/EEG study. Brain Res Bull. 2006; 69 86-94
24 Kocmur M, Milcinski M, Budihna N V. Evaluation of brain perfusion with technetium-99m bicisate single-photon emission tomography in patients with depressive disorder before and after drug treatment. Eur J Nucl Med. 1998; 25 1412-1414
25 Teneback C C, Nahas Z, Speer A M. et al . Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. J Neuropsychiatry Clin Neurosci. 1999; 11 426-435
26 Catafau A M, Perez V, Gironell A. et al . SPECT mapping of cerebral activity changes induced by repetitive transcranial magnetic stimulation in depressed patients. A pilot study. Psychiatry Res. 2001; 106 151-160
27 Mottaghy F M, Keller C E, Gangitano M. et al . Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients. Psychiatry Research Neuroimaging. 2002; 115 1-14
28 Kimbrell T A, Little J T, Dunn R T. et al . Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol Psychiatry. 1999; 46 1603-1613
29 Eschweiler G W, Wegerer C, Schlotter W. et al . Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression. Psychiatry Research: Neuroimaging Section. 2000; 99 161-172
30 Luborzewski A, Schubert F, Seifert F. et al . Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression. J Psych Res. 2007; 41 606-615
31 Couturier J L. Efficacy of rapid-rate repetitive transcranial magnetic stimulation in the treatment of depression. A systematic review and meta-analysis. J Psychiatry Neurosci. 2005; 30 83-90
32 Paus T, Castro-Alamacos M A, Petrides M. Cortico-cortical connectivity of the human mid-dorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation. Eur J Neurosci. 2001; 14 1405-1411
33 Barrett J, Della-Maggiore V, Chouinard P A. et al . Mechanisms of action underlying the effect of repetitive transcranial magnetic stimulation on mood. Behavioral and brain imaging studies. Neuropsychopharmacology. 2004; 29 1172-1189
34 Rush A J, Giles D E, Schlesser M E. et al . The dexamethasone suppression test in patients with mood disorders. J Clin Psychiatry. 1996; 57 470-484
35 Holsboer F, Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev. 1996; 17 197-205
36 Ising M, Kunzel H E, Binder E B. et al . The combinded dexamethasone/CRH test as a potential surrogate marker in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29 1085-1093
37 Jackson I M. The thyroid axis and depression. Thyroid. 1998; 8 951-956
38 Purba J S, Hoogendijk W JG, Hofman M A. et al . Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch Gen Psychiat. 1996; 53 137-143
39 Keck M E, Wigger A, Welt T. et al . Vasopressin mediates, the response of the combined dexamethason/CRH test in hyper-anxious rats: implications for the pathogenesis of affective disorders. Neuropsychopharmacol. 2002; 26 94-105
40 Keck M E, Engelmann M, Muller M B. et al . Repetitive transcranial magnetic stimulation induces active coping strategies and attenuates the neuroendocrine stress response in rats. J Psychiatr Res. 2000; 34 265-276
41 Keck M E, Welt T, Post A. et al . Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects. Neuropsychopharmacol. 2001; 24 337-349
42 Keck M E. Neurobiologische Grundlagen des therapeutischen Einsatzes der repetitiven transkraniellen Magnetstimulation (rTMS) in der Psychiatrie. Nervenheilkunde. 2003; 22 253-260
43 Pridmore S. Rapid transcranial magnetic stimulation and normalization of the dexamethasone suppression test. Psychiatry Clin Neurosci. 1999; 53 33-37
44 Baeken C, De Raedt R, Leyman L. et al . The impact of one HF-rTMS session on mood and salivary cortisol in treatment resistant uni-polar melancholic depressed patients. J Affect Disorders. 2009; 113 100-108
45 Zwanzger P, Baghai T C, Padberg F. et al . The combined dexamethason-CRH test before and after repetitive transcranial magnetic stimulation (rTMS) in major depression. Psychoneuroendocrinology. 2003; 28 376-385
46 Szuba M P, O’Reardon J P, Rai A S. et al . Acute mood and thyroid stimulating hormone effects of transcranial magnetic stimulation in major depression. Biol Psychiatry. 2001; 50 22-27
47 Cohrs S, Tergau F, Korn J. et al . Suprathreshold repetitive transcranial magnetic stimulation elevates thyroid-stimulating hormone in healthy male subjects. J Nerv Ment Dis. 2001; 189 393-397
48 George M S, Wassermann E M, Williams W A. et al . Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation (rTMS) of the prefrontal cortex. J Neuropsychiatry Clin Neurosci. 1996; 8 172-180
49 Evers S, Hengst K, Pecuch P W. The impact of repetitive transcranial magnetic stimulation on pituitary hormone levels and cortisol in healthy subjects. J of Affective Disorders. 2001; 66 83-88
50 Yukimasa T, Yoshimura R, Tamagawa A. et al . High-frequency repetitive transcranial magnetic stimulation improves refractory depression by influencing catecholamine and brain-derived neurotrophic factors. Pharmacopsychiatry. 2006; 39 52-59
51 Zanardini R, Gazzoli A, Ventriglia M. et al . Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. J Affect Disord. 2006; 91 83-86
52 Lang U E, Bajbouj M, Gallinat J. et al . Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation. Psychopharmacology. 2006; 187 56-59
53 Wolkin A, Sanfilipo M, Wolf A P. et al . Negative Symptoms and Hypofrontality in chronic schizophrenia. Arch Gen Psychiatry. 1992; 49 959-965
54 Andreasen N C, O’Leary D S, Flaum M. et al . Hypofrontality in schizophrenia: disturbed dysfunctional circuits in neuroleptic-naive patients. Lancet. 1997; 349 1730-1734
55 Callicott J H, Mattay V S, Verchinski B A. et al . Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry. 2003; 160 2209-2215
56 Holi M M, Eronen M, Toivonen K. et al . Left prefrontal repetitive transcranial magnetic stimulation in schizophrenia. Schizophr Bull. 2004; 30 429-434
57 Hajak G, Marienberg J, Langguth B. et al . High-frequency repetitive transcranial magnetic stimulation in schizophrenia: a combined treatment and neuroimaging study. Psychol Med. 2004; 34 1157-1163
58 Standford A D, Sharif Z, Corcoran C. et al . rTMS strategies for the study and treatment of schizophrenia: a review. Int J Neuropsychopharmacol. 2008; 11 563-576
59 Jandl M, Bittner R, Sack A. et al . Changes in negative symptoms and EEG in schizophrenic patients after repetitive transcranial magnetic stimulation (rTMS): an open-label pilot study. J Neural Transm. 2005; 112 955-967
60 Jin Y, Potkin S G, Kemp A S. et al . Therapeutic effects of individualized alpha frequency transcranial magnetic stimulation (alphaTMS) on the negative symptoms of schizophrenia. Schizophr Bull. 2006; 32 556-561
61 Lanzenberger R, Kasper S. Neuroimaging in schizophrenia. Fortschr Neurol Psychiat. 2005; 73 51-59
62 Konrad A, Winterer G. Disturbed structural connectivity in schizophrenia – primary factor in pathology or epiphenomenon?. Schizophr Bull. 2008; 34 72-92
63 Friston K J, Frith C D. Schizophrenia: a disconnection syndrome?. Clin Neurosci. 1995; 3 (2) 89-97
64 Meyer-Lindenberg A, Poline J B, Kohn P D. et al . Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. Am J Psychiatry. 2001; 158 1809-1817
65 Winterer G, Weinberger D R. Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends Neurosci. 2004; 27 683-690
66 Winterer G. Cortical microcircuits in schizophrenia – the dopamine hypothesis revisited. Pharmacopsychiatry. 2006; 39 (Suppl 1) 68-71
67 Rolls E T, Loh M, Deco G. et al . Computational models of schizophrenia and dopamine modulation in the prefrontal cortex. Nat Rev Neurosci. 2008; 9 (9) 696-709
68 Keck M E, Sillaber I, Ebner K. et al . Acute repetitive transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. Eur J Neurosci. 2000; 12 3713-3720
69 Sesack S R, Pickel V M. Prefrontal Cortex efferents in the rat synapseon unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and in dopamine neurons in the ventral tegmental area. J Com Neurol. 1992; 320 145-160
70 Keck M E, Welt T, Muller M B. et al . Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system. Neuropsychopharmacology. 2002; 43 101-109
71 Zangen A, Hyodo K. Transcranial magnetic stimulation induces increases in extracellular levels of dopamine and glutamate in the nucleus accumbens. Neuroreport. 2002; 13 2401-2405
72 Strafella A P, Paus T, Barrett J. et al . Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J Neurosci. 2001; 21 RC 157
73 Strafella A P, Paus T, Fraraccio M. et al . Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain. 2003; 126 2609-2615
74 Pogarell O, Koch W, Pöpperl G. et al . Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study. J Psychiatr Res. 2006; 40 307-314
75 Pogarell O, Koch W, Pöpperl G. et al . Acute rTMS increases striatal dopamine to a similar degree as D-amphetamine. Psychiatry Res. 2007; 156 251-255
76 Zwanzger P, Ella R, Keck M E. et al . Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depression. Biol Psychiatry. 2002; 51 602-603
77 Juckel G, Mendlin A, Jacobs B. Electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: implications for electroconvulsive therapy and transcranial magnetic stimulation in depression. Neuropsychopharmacology. 1999; 21 391-398
78 Kanno M, Matsumoto M, Togashi H. et al . Effects of repetitive transcranial magnetic stimulation on behavioural and neurochemical changes in rats during an elevated plus-maze-test. J Clin Neurosci. 2003; 211 5-14
79 Sibon I, Strafella A P, Gravel P. et al . Acute prefrontal cortex TMS in healthy volunteers: effects on brain 11C-alphaMtrp trapping. NeuroImage. 2007; 34 1658-1664
80 Müller M B, Toschi N, Kresse A E. et al . Longterm repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain. Neuropsychopharmacology. 2000; 23 205-215
81 Keck M E, Welt T, Erhardt A. et al . Neuroendokrine Effekte der repetitiven transkraniellen Magnetstimulation – Fokus auf Dopamin und Vasopressin. Nervenheilkunde. 2003; 22 346-0
82 Hoffman R E, Hawkins K A, Gueorguieva R. et al . Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Arch Gen Psychiatry. 2003; 60 49-56
83 Hoffman R E, Gueorguieva R, Hawkins K A. et al . Temporoparietal transcranial magnetic stimulation for auditory hallucinations: Safety, efficacy and moderators in a fifty patient sample. Biol Psychiatry. 2005; 58 97-104
84 Aleman A, Sommer I E, Kahn R S. Efficacy of slow repetitive transcranial magnetic stimulation in the treatment of resistent auditory hallucinations in schizophrenia: A meta-analysis. J Clin Psychiatry. 2007; 68 416-421
85 Silbersweig D A, Stern E, Frith C. et al . A functional neuroanatomy of hallucinations in schizophrenia. Nature. 1995; 378 176-179
86 Brunelin J, Poulet E, Bediou B. et al . Low frequency repetitive transcranial magnetic stimulation improves source monitoring deficit in hallucinating patients with schizophrenia. Schizophr Res. 2006; 81 41-45
87 Hoffman R E, Hampson M, Wu K. et al . Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation. Cereb Cortex. 2007; 17 2733-2743
88 McIntosh A M, Semple D, Tasker K. et al . Transcranial magnetic stimulation for auditory hallucinations in schizophrenia. Psychiatry Res. 2004; 127 9-17
89 Fitzgerald P B, Brown T L, Benitez J. et al . A double-blind sham-controlled trial of repetitive transcranial magnetic stimulation in the treatment of refractory auditory hallucinations. J Clin Psychopharmacol. 2005; 25 358-362
90 Schönfeldt-Lecuona C, Gron G, Walter H. et al . Stereotaxic rTMS for the treatment of auditory hallucinations in schizophrenia. Neuroreport. 2004; 15 1669-1673
91 Jandl M, Steyer J, Weber M. et al . Treating auditory hallucinations by transcranial magnetic stimulation: a randomized controlled cross-over trial. Neuropsychobiology. 2006; 53 63-69
92 Horacek J, Brunovsky M, Novak T. et al . Effect of low-frequency rTMS on electromagnetic tomography (LORETA) and regional brain metabolism (PET) in schizophrenia patients with auditory hallucinations. Neuropsychobiol. 2007; 55 132-142
93 Rosa M O, Gattaz W F, Rosa M A. et al . Effects of repetitive transcranial magnetic stimulation on auditory hallucinations refractory to clozapine. J Clin Psychiatry. 2007; 68 1528-1532
94 Langguth B, Eichhammer P, Kreutzer A. et al . The impact of auditory cortex activity on characterizing and treating patients with chronic tinnitus – first results from a PET study. Acta Otolaryngol Suppl. 2006; 556 84-88
95 Lockwood A H, Salvi R J, Coad M L. et al . The functional neuroanatomy of tinnitus: evidence for limbic system links and neural plasticity. Neurology. 1998; 50 114-120
96 Lockwood A H, Wack D S, Burkard R F. et al . The functional anatomy of gaze-evoked tinnitus and sustained lateral gaze. Neurology. 2001; 56 472-480
97 Giraud A L, Chery-Croze S, Fischer G. et al . A selective imaging of tinnitus. Neuroreport. 1999; 10 1-5
98 Mirz F, Pedersen B, Ishizu K. et al . Positron emission tomography of cortical centers of tinnitus. Hear Res. 1999; 134 133-144
99 Eichhammer P, Langguth B, Marienhagen J. et al . Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: a short case series. Biol Psychiatry. 2003; 54 862-865
100 Langguth B, Zowe M, Landgrebe M. et al . Transcranial magnetic stimulation for the treatment of tinnitus: a new coil positioning method and first results. Brain Topography. 2006; 18 241-247
101 Plewnia C, Reimold M, Najib A. et al . Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation. Human Brain Mapp. 2007; 28 238-246
102 Plewnia C, Reimold M, Najib A. et al . Moderate therapeutic efficacy of PET-navigated repetitive transcranial magnetic stimulation against chronic tinnitus: a randomised, controlled pilot study. J Neurol Neurosurg Psychiatry. 2007; 78 152-156
103 Richter G T, Mennemeier M, Bartel T. et al . Transcranial magnetic stimulation for tinnitus: a case study. Laryngoscope. 2006; 116 1867-1872
104 May A, Hajak G, Gänsbauer S. et al . Structural brain alterations following 5 days of intervention: Dynamic aspects of neuroplasticity. Cerebral Cortex. 2007; 17 205-210
105 Huang Y Z, Edwards M J, Rounis E. et al . Theta burst stimulation of the human motor cortex. Neuron. 2005; 45 201-206
106 Paulus W. Towards establishing a therapeutic window for rTMS by theta burst stimulation. Neuron. 2005; 45 181-183
107 Talelli P, Greenwood R J, Rothwell J C. Exploring Theta Burst Stimulation as an intervention to improve motor recovery in chronic stroke. Clin Neurophysiol. 2007; 118 333-342
108 Schutter D J, Honk van J. A framework for targeting alternative brain regions with repetitive transcranial magnetic stimulation in the treatment of depression. J Psychiatry Neurosci. 2005; 30 (2) 91-7
109 Fitzgerald P B, Benitez J, Castella de A. et al . A randomized, controlled trial of sequential bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression. Am J Psychiatry. 2006; 163 (1) 88-94
110 Schule C, Zwanzger P, Baghai T. et al . Effects of antidepressant pharmacotherapy after repetitive transcranial magnetic stimulation in major depression: an open label follow-up study. J Psychiatr Research. 2003; 37 145-153
111 Mobascher A, Boecker J, Malevani J. et al . Repetitive transcranial magnetic stimulation as an antidepressant monotherapy in a patient with major depression, leucocytopenia and rhabdomyolysis. Int J Neuropsychopharmacol. 2004; 7 527-529
112 O’Reardon J P, Blumner K H, Peshek A D. et al . Long-term maintenance therapy for major depressive disorder with rTMS. J Clin Psychiatry. 2005; 66 1524-1528
113 Schönfeldt-Lecuona, Walter H, Connemann B J. et al . Historical Review and recent research trends of the antidepressant repetitive transcranial magnetic stimulation (rTMS). Fortschritte der Neurol. 2002; 70 520-530
114 De Ridder D, De Muller G, Verstraten E. et al . Primary and secondary auditory cortex stimulation for intractable tinnitus. ORL J Otorhinolaryngol Relat Spec. 2006; 68 48-55

Dr. Joachim Cordes

Klinik und Poliklinik für Psychiatrie und Psychotherapie der Heinrich-Heine-Universität

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40629 Düsseldorf

Email: joachim.cordes@lvr.de