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DOI: 10.1055/s-0028-1109758
© Georg Thieme Verlag KG Stuttgart · New York
Yohimbin, ein Alpha-2-Antagonist: Literaturübersicht zu psychiatrisch relevanten Wirkungen und Nebenwirkungen mit aktuellem Fallbericht
Psychiatric Effects and Side Effects of the Alpha-2-Antagonist Yohimbine: A Review of Literature and Case ReportPublication History
Publication Date:
09 October 2009 (online)
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Zusammenfassung
Wir beschreiben den Fall einer 21-jährigen Patientin, die 2-malig den Alpha-2-Antagonisten Yohimbin zur Gewichtsreduktion einnahm. In engem zeitlichem Zusammenhang mit dem Beginn der Einnahme standen Verhaltensauffälligkeiten, Änderungen in Konsumverhalten und Suchterleben (Alkohol, Kokain) und Suizidalität. Daten aus präklinischen und klinischen Studien werden diskutiert, die einen möglichen kausalen Zusammenhang untermauern. Vorangestellt ist eine Literaturübersicht über psychische Wirkungen und Nebenwirkungen von Yohimbin.
Abstract
We describe a 21-year old female patient who had taken the alpha-2-antagonist yohimbine for weight-loss. The patient reported alterations in alcohol- and cocaine-seeking along with changes in defensive behaviour, including suicidal tendencies. Pre-clinical and clinical studies are discussed, which support the hypothesis of a causal relationship. We added an overview of relevant psychiatric effects and side effects of yohimbine.
Schlüsselwörter
Yohimbin - Kokain - Alkohol - Verhalten - Suizidalität
Key words
Yohimbine - cocaine - alcohol - behaviorial alterations - suicidality
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Martin Scherr
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universität München
Ismaningerstraße 22
81675 München
Email: martin_scherr@hotmail.com