Planta Med 2009; 75(3): 249-255
DOI: 10.1055/s-0028-1112202
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Wittiorumins A – F, Antioxidant Diels-Alder-Type Adducts from Morus wittiorum

Yong-Xia Tan1 , Ren-Yi Yan1 , Hong-Qing Wang1 , Ruo-yun Chen1 , De-Quan Yu1
  • 1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China
Further Information

Publication History

Received: June 30, 2008 Revised: October 8, 2008

Accepted: October 19, 2008

Publication Date:
09 January 2009 (online)

Abstract

Six new Diels-Alder-type adducts, wittiorumins A-F (1 – 6) along with the three known compounds chalcomoracin (7), mulberrofuran J (8), and mongolicin F (9), were isolated from the stem bark of Morus wittiorum. Their structures including their absolute configurations were determined on the basis of spectroscopic analysis and chemical methods. Some of the isolated compounds (1 – 4) were assayed for their antioxidant activities, among which compounds 1 – 3 were active as antioxidants, with inhibitory ratios of 73.0 %, 82.0 %, and 82.0 %, respectively, at a concentration of 10 – 5 M.

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Prof. Ruo-Yun Chen

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