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Planta Med 2009; 75(4): 335-337
DOI: 10.1055/s-0028-1112215
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Acetylcholinesterase Activity of Alkaloids from the Leaves of Waltheria brachypetala

Murilo M. C. Lima1 , Jorge A. López2 , Jorge M. David1 , Eliezer P. Silva1 , Ana M. Giulietti3 , Luciano P. de Queiroz3 , Juceni P. David2
  • 1Intituto de Química, Universidade Federal da Bahia, Campus de Ondina, Salvador (BA), Brazil
  • 2Faculdade de Farmácia, Universidade Federal da Bahia, Campus de Ondina, Salvador (BA), Brazil
  • 3Departamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Feira de Santana (BA), Brazil
Weitere Informationen

Publikationsverlauf

Received: October 14, 2008 Revised: November 4, 2008

Accepted: November 10, 2008

Publikationsdatum:
19. Dezember 2008 (online)

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Abstract

Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.

Abbreviations

AChE:acetylcholinesterase

DTNB:5,5′-dithio-bis(2-nitrobenzoic acid)

Key words

Waltheria brachypetala - Sterculiaceae - quinolinone alkaloids - acetylcholinesterase inhibitors

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Prof. Dr. Juceni P. David

Faculdade de Farmácia

Universidade Federal da Bahia

40170–280, Salvador, BA

Brazil

Telefon: +55-71-3235-9350

Fax: +55-71-3235-5166

eMail: juceni@ufba.br