Acetylcholinesterase Activity of Alkaloids from the Leaves of Waltheria brachypetala

Abstract

Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.

Abbreviations

AChE:acetylcholinesterase

DTNB:5,5′-dithio-bis(2-nitrobenzoic acid)

Waltheria brachypetala - Sterculiaceae - quinolinone alkaloids - acetylcholinesterase inhibitors

References

• 1 Gressler V, Stueker C Z, Dias G, Dalcol de OC I I, Burrow R A, Schmidt J. Quinolone alkaloids from Waltheria douradinha. .  Phytochemistry. 2008;  69 994-9
• 2 Pais M, Marchand J, Jarreau F X, Goutarel R. Peptide alkaloids: Structures of adouetines X, Y. Y′, and Z, the alkaloids of Waltheria americana (Sterculiaceae).  Bull Soc Chim Fr. 1968;  3 1145-8
• 3 Bhakuni R S, Shukla Y N, Thakur R S. Melochicorine, a pseudooxindole alkaloid from Melochia corchorifolia. .  Phytochemistry. 1991;  9 3159-60
• 4 Kapadia G J, Shukla Y N. Melosatin D. A new isatin alkaloid from Melochia tomentosa roots.  Planta Med. 1993;  59 568-9
• 5 Dias G CD, Morel A F, Gressler V, Hoelzel S CSM, Silva U F, Dalcol I I. Alkaloids from Melochia chamaedrys. .  Planta Med. 2007;  73 289-92
• 6 Emile A, Waikedre J, Herrenknecht C, Fourneau C, Gantier J C, Hnawia E. Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. .  Phytother Res. 2000;  21 398-400
• 7 Pattara T, Apiruk P, Udom K, Warinthorn C. Coumarins from the heartwoods of Mansonia gagei Drumm.  Phytochemistry. 2002;  60 773-6
• 8 Shukla Y N, Sokoloski E A, Fales H M, Kapadia G J. Potential carcinogens. Part 8. 6-Methoxy-7,8-methylenedioxycoumarin from Melochia tomentosa. .  Phytochemistry. 1976;  15 1788
• 9 Wang R F, Yang X W, Ma C M, Shang M Y, Liang J Y, Wang X. et al . Alkaloids from the seeds of Sterculia lychonophora (Pangdahai).  Phytochemistry. 2003;  63 475-8
• 10 Ellman G L, Courtney K D, Andres V, Featherstone R M. A new and rapid colorimetric determination of acetylcholinesterase activity.  Biochem Pharmacol. 1961;  7 88-95