Endoscopy 2009; 41(4): 310-315
DOI: 10.1055/s-0028-1119639
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Magnifying endoscopy combined with narrow-band imaging for differential diagnosis of superficial depressed gastric lesions

M.  Kaise1 , M.  Kato1 , M.  Urashima2 , Y.  Arai1 , H.  Kaneyama1 , Y.  Kanzazawa1 , J.  Yonezawa1 , Y.  Yoshida1 , N.  Yoshimura1 , T.  Yamasaki1 , K.  Goda1 , H.  Imazu1 , H.  Arakawa1 , K.  Mochizuki1 , 3 , H.  Tajiri1 , 3
  • 1Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
  • 2Department of Clinical Research and Development, The Jikei University School of Medicine, Tokyo, Japan
  • 3Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan
Further Information

Publication History

submitted 12 February 2008

accepted after revision 9 December 2008

Publication Date:
01 April 2009 (online)

Background and aim:Magnifying endoscopy combined with narrow-band imaging (ME-NBI) has been used for differential diagnosis of various focal lesions. The aim of our study was to evaluate ME-NBI criteria for cancer diagnosis in superficial depressed gastric lesions in comparison to conventional white light endoscopy (WLE).

Patients and methods:ME-NBI and WLE images of 100 superficial gastric depressions (55 depressed cancers, 45 benign depressions) were independently evaluated by 11 endoscopists blinded to the diagnosis in each case. The presence or absence of predefined ME-NBI findings relating to microvasculature and fine mucosal structure (FMS) was recorded. A general diagnosis of benign or malignant also had to be given on the basis of a general assessment of features of color and shape as shown in the ME-NBI and WLE images, respectively, without regard to any prespecified criteria.

Results:Multivariate and ROC analysis demonstrated that the triad of FMS disappearance, microvascular dilation, and heterogeneity appeared to be the best combination for diagnosis of gastric cancer. ME-NBI diagnosis with the triad attained a good specificity (85 %, theoretically calculated if all of the triad were positive), which was significantly (P < 0.001) superior to WLE general diagnosis (65 %), and comparable with ME-NBI general diagnosis (80 %). The sensitivities of the three diagnoses (ME-NBI with the triad 69 %, WLE general diagnosis 71 %, ME-NBI general diagnosis 72 %) were comparably moderate. The κ values (interobserver concordance) for ME-NBI diagnosis with the triad (0.47) and ME-NBI general diagnosis (0.48) were superior to the κ value for WLE diagnosis (0.34).

Conclusion:The triad of FMS disappearance, microvascular dilation, and heterogeneity has good specificity for the diagnosis of superficial depressed gastric carcinoma, but the sensitivity needs to be improved.

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M. KaiseMD 

Department of Endoscopy
The Jikei University School of Medicine

3-25-8, Nishishinbashi, Minato-ku
Tokyo 105-8461
Japan

Fax: +81-3-34594524

Email: kaise@jikei.ac.jp