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Planta Med 2009; 75(10): 1168-1170
DOI: 10.1055/s-0029-1185449
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

15-Lipoxygenase Inhibitory Effects of Prenylated Flavonoids from Erythrina senegalensis

Adiaratou Togola1 , 2 , Berte Hedding1 , Anette Theis1 , Helle Wangensteen1 , Frode Rise3 , Berit Smestad Paulsen1 , Drissa Diallo2 , Karl Egil Malterud1
  • 1Section of Pharmacognosy, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, Oslo, Norway
  • 2Département de Médecine Traditionnelle, Institut National de Recherche en Santé Publique, Bamako, Mali
  • 3Department of Chemistry, University of Oslo, Oslo, Norway
Weitere Informationen

Publikationsverlauf

received December 17, 2008 revised January 28, 2009

accepted February 3, 2009

Publikationsdatum:
13. März 2009 (online)

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Abstract

One new pterocarpan (named erybraedin F) along with seven known prenylated flavonoids were isolated from the stem and root bark of the medicinal plant Erythrina senegalensis. The structures were elucidated by 1D and 2D NMR and MS. The pterocarpans were found to be strong inhibitors of 15-lipoxygenase.

Key words

Erythrina senegalensis (Fabaceae) - pterocarpans - flavonoid - DPPH - 15‐lipoxygenase

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Karl Egil Malterud

Department of Pharmaceutical Chemistry
Division of Pharmacognosy
School of Pharmacy
University of Oslo

P. O. Box 1068

0316 Oslo

Norway

Telefon: + 47 22 85 65 63

eMail: k.e.malterud@farmasi.uio.no