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Planta Med 2009; 75(7): 763-775
DOI: 10.1055/s-0029-1185450
Plant Analysis
Review
© Georg Thieme Verlag KG Stuttgart · New York

Quality Control of Herbal Material and Phytopharmaceuticals with MS and NMR Based Metabolic Fingerprinting

Frank van der Kooy1 , Federica Maltese1 , Young Hae Choi1 , Hye Kyong Kim1 , Robert Verpoorte1
  • 1Division of Pharmacognosy, Section of Metabolomics, Institute of Biology, Leiden University, Leiden, The Netherlands
Further Information

Publication History

received July 30, 2008 revised January 19, 2009

accepted February 2, 2009

Publication Date:
13 March 2009 (online)

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Abstract

Metabolic fingerprinting techniques have received a lot of attention in recent years and the annual amount of publications in this field has increased significantly over the past decade. This increase in publications is due to improvements in the analytical performance, most notably in the field of NMR and MS analysis, and the increased awareness of the different applications of this growing field. Metabolomic fingerprinting or profiling is continuously being applied to new areas of research such as drug discovery from natural resources, quality control of herbal material, and discovering lead compounds. In this review the current state of the art of metabolic fingerprinting, focussing on NMR and MS technologies will be discussed. The application of these two analytical tools in the quality control of herbal material and phytopharmaceuticals forms the major part of this review. Finally we will look at the future developments and perspectives of these two technologies in the quality control of herbal material.

Key words

metabolic fingerprinting - NMR - MS - medicinal plants - herbal plant preparations

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Dr. Frank van der Kooy

Division of Pharmacognosy
Section of Metabolomics
Institute of Biology
Leiden University

Einsteinweg 55

PO Box 9502

2300RA Leiden

Netherlands

Phone: + 31 7 15 27 44 71

Fax: + 31 7 15 27 45 11

Email: frank.vanderkooy@chem.leidenuniv.nl