Planta Med 2009; 75(11): 1262-1265
DOI: 10.1055/s-0029-1185523
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A New Chalcone Glycoside, a New Tetrahydrofuranoid Lignan, and Antioxidative Constituents from the Stems and Leaves of Viburnum propinquum

Xiao-Yu Wang1 , Hai-Ming Shi1 , Li Zhang2 , Xiao-Bo Li1
  • 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P. R. China
  • 2Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China
Weitere Informationen

Publikationsverlauf

received October 13, 2008 revised February 16, 2009

accepted February 26, 2009

Publikationsdatum:
27. März 2009 (online)

Abstract

A new chalcone glycoside (2) and a new tetrahydrofuranoid lignan (3), along with 12 known compounds, were isolated from the stems and leaves of Viburnum propinquum Hemsl. The structures of all isolated compounds were deduced using spectroscopic and chemical methods. Antioxidative activities of most phenolic compounds were evaluated. Compounds 1 (3,4,2′,4′-tetrahydroxy-trans-chalcone), 2 (3,4,2′,4′-tetrahydroxy-trans-chalcone-2′-O-β-D-glucoside), 12 (quercetin), 13 ((+)-dihydroquercetin), and 14 (eriodictyol) showed antioxidative capacities in the DPPH and hydroxyl free-radical assays, with IC50 values of 3.80–6.12 µg/mL, and 9.24–11.87 µg/mL, respectively. Compounds 1, 2, 12, 13, and 14 also exhibited inhibitory activities against lipid peroxidation in rat liver homogenate, with an inhibitory rate of 10.8–39.9 % at 20 µg/mL, 38.8–57.2 % at 100 µg/mL, and 44.2–72.4 % at 200 µg/mL, respectively.

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Prof. Dr. Xiao-Bo Li

School of Pharmacy
Shanghai Jiao Tong University

No. 800 Dongchuan Road

Minhang District

Shanghai 200240

People's Republic of China

Telefon: + 86 21 34 20 48 06

Fax: + 86 21 34 20 48 04

eMail: xbli@sjtu.edu.cn