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DOI: 10.1055/s-0029-1185526
© Georg Thieme Verlag KG Stuttgart · New York
Pigmentierte villonoduläre Synovitis der thorakalen Wirbelsäule – operatives Langzeitergebnis: ein Fallbericht
Pigmented Villonodular Synovitis Involving the Thoracic Spine: A Case ReportPublication History
Publication Date:
08 April 2009 (online)
Zusammenfassung
Spinale diffuse Riesenzelltumoren (auch als pigmentierte villonoduläre Synovitis bekannt [PVNS]) sind benigne. Obwohl das Auftreten an der thorakalen Wirbelsäule sehr selten ist, sollte es dennoch differenzialdiagnostisch in Betracht gezogen werden. Wir berichten über den Fall eines 35-jährigen Patienten, bei dem eine expansiv in den Spinalkanal von C7-Th2, intraspinal das Rückenmark komprimierend wachsende Raumforderung mit osteolytischen Veränderungen operativ behandelt wurde. Die histopathologische Diagnose war eine PVNS. In der 2-Jahres-Kontrolle war der Patient beschwerdefrei und es zeigt sich bildmorphologisch kein Anhalt auf einen Rezidivtumor.
Abstract
Spinal diffuse-type giant cell tumours (also known as pigmented villonodular synovitis [PVNS]) are benign. Their occurrence in the thoracic spine is a very rare entity, nevertheless it should be considered in the differential diagnosis. We report about the case of a 35-year-old male presenting with an osteolytic and expansive mass compressing the spinal cord from C7 to Th2. Surgical resection was performed. Histopathological diagnosis was PVNS. 2 years postoperatively the patient was without pain and fully reintegrated in his previous job as a physician.
Schlüsselwörter
Riesenzelltumor - thorakale Wirbelsäule - pigmentierte villonoduläre Synovitis
Key words
giant cell tumour - thoracic spine - pigmented villonodular synovitis
Literatur
- 1 Rao A S, Vigorita V J. Pigmented villonodular synovitis (giant-cell tumor of the tendon sheath and synovial membrane). A review of eighty-one cases. J Bone Joint Surg [Am]. 1984; 66 76-94
- 2 Jaffe H L, Lichtenstein L, Sutro C J. Pigmented villonodular synovitis, bursitis and tendosynovitis. Discussion of synovial and bursal equivalents of tendosynovial lesion commonly denoted as xanthoma, xanthogranuloma, giant cell tumor or myeloplaxoma of tendon sheat, with some considerations of this tendon sheat lesion itself. Arch Pathol. 1941; 31 731-765
- 3 Flandry F, Hughston J C. Pigmented villonodular synovitis. J Bone Joint Surg [Am]. 1987; 69 942-949
- 4 Al-Nakshabandi N A, Ryan A G, Choudur H. et al . Pigmented villonodular synovitis. Clin Radiol. 2004; 59 414-420
- 5 Llauger J, Palmer J, Roson N. et al . Pigmented villonodular synovitis and giant cell tumors of the tendon sheath: radiologic and pathologic features. AJR Am J Roentgenol. 1999; 172 1087-1091
- 6 Ly J Q, Carlson C L, LaGatta L M. et al . Giant cell tumor of the peroneus tendon sheath. AJR Am J Roentgenol. 2003; 180 1442
- 7 Huang G S, Lee C H, Chan W P. et al . Localized nodular synovitis of the knee: MR imaging appearance and clinical correlates in 21 patients. AJR Am J Roentgenol. 2003; 181 539-543
- 8 Jelinek J S, Kransdorf M J, Shmookler B M. et al . Giant cell tumor of the tendon sheath: MR findings in nine cases. AJR Am J Roentgenol. 1994; 162 919-922
- 9 Bui-Mansfield L T, Youngberg R A, Coughlin W. et al . MRI of giant cell tumor of the tendon sheath in the cervical spine. J Comput Assist Tomogr. 1996; 20 113-115
- 10 Karasick D, Karasick S. Giant cell tumor of tendon sheath: spectrum of radiologic findings. Skeletal Radiol. 1992; 21 219-224
- 11 Mahmood A, Caccamo D V, Morgan J K. Tenosynovial giant-cell tumor of the cervical spine. Case report. J Neurosurg. 1992; 77 952-955
- 12 Dingle S R, Flynn J C, Flynn Jr J C. et al . Giant-cell tumor of the tendon sheath involving the cervical spine. A case report. J Bone Joint Surg [Am]. 2002; 84 1664-1667
- 13 Gezen F, Akay K M, Aksu A Y. et al . Spinal pigmented villonodular synovitis: a case report. Spine. 1996; 21 642-645
- 14 Motamedi B, Richards R S. Giant cell tumor of the proximal phalanx: a case report. Ann Plast Surg. 1997; 39 314-316
- 15 Anazawa U, Hanaoka H, Shiraishi T. et al . Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. Ultrastruct Pathol. 2006; 30 151-158
- 16 Sciot R, Rosai J, Dal Cin P. et al . Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. Mod Pathol. 1999; 12 576-579
- 17 Kleinman G M, Dagi T F, Poletti C E. Villonodular synovitis in the spinal canal: case report. J Neurosurg. 1980; 52 846-848
- 18 Campbell A J, Wells I P. Pigmented villonodular synovitis of a lumbar vertebral facet joint. J Bone Joint Surg [Am]. 1982; 64 145-146
- 19 Pulitzer D R, Reed R J. Localized pigmented villonodular synovitis of the vertebral column. Arch Pathol Lab Med. 1984; 108 228-230
- 20 Weidner N, Challa V R, Bonsib S M. et al . Giant cell tumors of synovium (pigmented villonodular synovitis) involving the vertebral column. Cancer. 1986; 57 2030-2036
- 21 Retrum E R, Schmidlin T M, Taylor W K. et al . CT myelography of extradural pigmented villonodular synovitis. AJNR Am J Neuroradiol. 1987; 8 727-729
- 22 Karnezis T A, McMillan R D, Ciric I. Pigmented villonodular synovitis in a vertebra. A case report. J Bone Joint Surg [Am]. 1990; 72 927-930
- 23 Kuwabara H, Uda H, Nakashima H. Pigmented villonodular synovitis (giant cell tumor of the synovium) occurring in the vertebral column. Report of a case. Acta Pathol Jpn. 1992; 42 69-74
- 24 Khoury G M, Shimkin P M, Kleinman G M. et al . Computed tomography and magnetic resonance imaging findings of pigmented villonodular synovitis of the spine. Spine. 1991; 16 1236-1237
- 25 Clark L J, McCormick P W, Domenico D R. et al . Pigmented villonodular synovitis of the spine. Case report. J Neurosurg. 1993; 79 456-459
- 26 Titelbaum D S, Rhodes C H, Brooks J S. et al . Pigmented villonodular synovitis of a lumbar facet joint. AJNR Am J Neuroradiol. 1992; 13 164-166
- 27 Giannini C, Scheithauer B W, Wenger D E. et al . Pigmented villonodular synovitis of the spine: a clinical, radiological, and morphological study of 12 cases. J Neurosurg. 1996; 84 592-597
- 28 Bruecks A K, Macaulay R J, Tong K A. et al . November 2000: 13 year old girl with back pain and leg weakness. Brain Pathol. 2001; 11 263-264
- 29 Dimeco F, Rizzo P, Li K W. et al . Pigment villonodular synovitis of the spine. Case report and review of the literature. J Neurosurg Sci. 2001; 45 216-219
- 30 Furlong M A, Motamedi K, Laskin W B. et al . Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis. Hum Pathol. 2003; 34 670-679
- 31 Parmar H A, Sitoh Y Y, Tan K K. et al . MR imaging features of pigmented villonodular synovitis of the cervical spine. AJNR Am J Neuroradiol. 2004; 25 146-149
- 32 Hermann J, Stadlmaier E, Aigner C. et al . [Erosive intervertebral joint lesions. A case of pigmented villonodular synovitis]. Z Rheumatol. 2007; 66 152 154-156
- 33 Hansen M A, Harper C, Yiannikas C. et al . A rare presentation of pigmented villonodular synovitis. J Clin Neurosci. 2007; 14 386-388
- 34 Oe K, Sasai K, Yoshida Y. et al . Pigmented villonodular synovitis originating from the lumbar facet joint: a case report. Eur Spine J. 2007; 16 (Suppl. 3) 301-305
- 35 Finn M A, McCall T D, Schmidt M H. Pigmented villonodular synovitis associated with pathological fracture of the odontoid and atlantoaxial instability. Case report and review of the literature. J Neurosurg Spine. 2007; 7 248-253
- 36 Rovner J, Yaghoobian A, Gott M. et al . Pigmented villonodular synovitis of the zygoapophyseal joint: a case report. Spine. 2008; 33 E656-E658
Dr. Ioannis Pechlivanis
Universitätsmedizin Mannheim
Medizinische Fakultät Mannheim der Universität Heidelberg
Theodor-Kutzer-Ufer 1–3
68167 Mannheim
Phone: 06 21/3 83 23 60
Fax: 06 21/3 83 20 04
Email: ioannis.pechlivanis@nch.ma.uni-heidelberg.de