Planta Med 2009; 75(11): 1253-1257
DOI: 10.1055/s-0029-1185537
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Dibenzocyclooctadiene Lignans and Lanostane Derivatives from the Roots of Kadsura coccinea and their Protective Effects on Primary Rat Hepatocyte Injury Induced by t-Butyl Hydroperoxide

Ninh Khac Ban1 , Bui Van Thanh1 , Phan Van Kiem2 , Chau Van Minh2 , Nguyen Xuan Cuong2 , Nguyen Xuan Nhiem4 , Hoang Thanh Huong2 , Ha Tuan Anh1 , Eun-Jeon Park3 , Dong Hwan Sohn3 , Young Ho Kim4
  • 1Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
  • 2Institute of Natural Products Chemistry, VAST, Hanoi, Vietnam
  • 3Institute of Pharmaceutical Research Development, Department of Pharmacy, Wonkwang University, Iksan, Korea
  • 4College of Pharmacy, Chungnam National University, Daejeon, Korea
Weitere Informationen

Publikationsverlauf

received Sept. 22, 2008 revised February 26, 2009

accepted March 4, 2009

Publikationsdatum:
06. April 2009 (online)

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Abstract

A new dibenzocyclooctadiene lignan, acetylepigomisin R (1), and a new 3,4-seco-lanostane-type triterpene, seco-coccinic acid F (2), along with three known dibenzocyclooctadiene lignans, isovaleroylbinankadsurin A (3), kadsuralignan J (4), and binankadsurin A (5), and one lanostane-type triterpene, 20(R),24(E)-3-oxo-9β-lanosta-7,24-dien-26-oic acid (6), were isolated from the methanol extract of the Kadsura coccinea roots. Their structures were elucidated on the basis of spectroscopic evidence including ESI‐MS, HR‐EI‐MS, 1D and 2D NMR. The protective effects of these compounds were evaluated in primary cultured rat hepatocytes intoxicated with 1.2 mM t-butyl hydroperoxide. Compounds 1, 3, and 5 showed protective effects with ED50 values of 135.7, 26.1, and 79.3 µM, respectively.

References

Prof. Dr. Young Ho Kim

College of Pharmacy
Chungnam National University

Daejeon 305-764

Korea

Telefon: + 82 4 28 21 59 33

Fax: + 82 4 28 23 65 66

eMail: yhk@cnu.ac.kr