Planta Med 2009; 75(11): 1246-1252
DOI: 10.1055/s-0029-1185542
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Investigation of Two Flacourtiaceae Plants: Bennettiodendron leprosipes and Flacourtia ramontchi

Xing-Yun Chai1 , Hong-Yan Ren1 , Zheng-Ren Xu1 , Chang-Cai Bai1 , Fei-Ran Zhou1 , Si-Kai Ling2 , Xiao-Ping Pu2 , Fei-Fei Li1 , Peng-Fei Tu1
  • 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, P. R. China
  • 2Department of Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, P. R. China
Further Information

Publication History

received Dec. 2, 2007 revised February 17, 2009

accepted February 20, 2009

Publication Date:
02 April 2009 (online)

Abstract

Investigations of two Flacourtiaceae plants, Bennettiodendron leprosipes and Flacourtia ramontchi, resulted in the isolation and structural elucidation of six new constituents including two phenolic glycosides (1 and 2), one lignan (3), two lignan glycosides (4 and 5), and a monoterpene glycoside (6), together with 22 known compounds (728). The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The selected isolates 1, 2, 810, 2226, and some phenolic glycosides 2942 previously isolated from another Flacourtiaceae plant, Itoa orientalis, were tested against snake venom phosphodiesterase I (PDE I) activity. The result indicated that 22, 30, 32, 34, and 40 exhibited moderate inhibitory activities against PDE I with the values ranging from 13.15 to 20.86 %, and 1, 8, 10, 25, 31, 33, 35, 38, 39, and 41 showed weak inhibitory activity.

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Prof. Peng-Fei Tu

State Key Laboratory of Natural and Biomimetic Drugs
School of Pharmaceutical Sciences
Peking University Health Science Center

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