Three New Naphthoquinone Pigments Isolated from the Freshwater Fungus, Astrosphaeriella papuana

Abstract

Three new naphthoquinones, astropaquinones A – C (1–3), were isolated from cultures of the freshwater fungus Astrosphaeriella papuana YMF 1.01181, together with the known compound, 6-hydroxy-2,4-dimethoxy-7-methylanthraquinone (4). The structures of the compounds were settled mainly by interpretation of their 1D and 2D NMR spectra. Astropaquinone B (2) and C (3) were found to possess a rare pyranonaphthoquinone skeleton containing a lactol ring. Furthermore, compounds 1–4 showed moderate antagonistic activity against nine fungi and four bacterial strains.

Key words

freshwater fungus - Astrosphaeriella papuana - pyranonaphthoquinone - astropaquinones - lactol ring - antimicrobial activity - Melanommataceae

References

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1 These authors contributed equally to this work.