Planta Med 2009; 75(11): 1191-1195
DOI: 10.1055/s-0029-1185717
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Salidroside, the Main Active Compound of Rhodiola Plants, Inhibits High Glucose-Induced Mesangial Cell Proliferation

Dengke Yin1 , 2 , Wenbing Yao1 , Song Chen1 , Rongfeng Hu2 , Xiangdong Gao1
  • 1School of Life Science and Technology, China Pharmaceutical University, Nanjing, P. R. China
  • 2School of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei, P. R. China
Further Information

Publication History

received Dec. 27, 2008 revised March 28, 2009

accepted April 7, 2009

Publication Date:
14 May 2009 (online)

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Abstract

Because Rhodiola plants are known to have a protective effect on diabetic nephropathy, this study aimed to investigate the inhibitory effect of salidroside, the main active component of Rhodiola plants, on high glucose-induced mesangial cell proliferation and its possible mechanism. Salidroside (1 ∼ 100 µM) dose dependently inhibited high glucose-induced mesangial cell early proliferation. Exposure of mesangial cells to high glucose for 24 h significantly induced reactive oxygen species (ROS) accumulation, ERK1/2 phosphorylation, and p27Kip1 expression, and these changes were dramatically inhibited by salidroside in a dose-dependent manner. High glucose-promoted TGF-β1 secretion was also significantly attenuated by treatment of mesangial cells with salidroside. These results indicated that salidroside had the ability to inhibit high glucose-induced mesangial cell proliferation, which is in correlation with salidroside suppressing TGF-β1 production and ERK1/2 phosphorylation.

References

Prof. Dr. Xiangdong Gao

School of Life Science and Technology
China Pharmaceutical University

24 Tongjia Road

Nanjing 210009

People's Republic of China

Phone: + 86 25 83 27 12 98

Fax: + 86 25 83 27 12 49

Email: xiangdon_gao@hotmail.com