Salidroside, the Main Active Compound of Rhodiola Plants, Inhibits High Glucose-Induced Mesangial Cell Proliferation

Abstract

Because Rhodiola plants are known to have a protective effect on diabetic nephropathy, this study aimed to investigate the inhibitory effect of salidroside, the main active component of Rhodiola plants, on high glucose-induced mesangial cell proliferation and its possible mechanism. Salidroside (1 ∼ 100 µM) dose dependently inhibited high glucose-induced mesangial cell early proliferation. Exposure of mesangial cells to high glucose for 24 h significantly induced reactive oxygen species (ROS) accumulation, ERK1/2 phosphorylation, and p27^Kip1 expression, and these changes were dramatically inhibited by salidroside in a dose-dependent manner. High glucose-promoted TGF-β1 secretion was also significantly attenuated by treatment of mesangial cells with salidroside. These results indicated that salidroside had the ability to inhibit high glucose-induced mesangial cell proliferation, which is in correlation with salidroside suppressing TGF-β1 production and ERK1/2 phosphorylation.

salidroside - high glucose - proliferation - TGF‐β1 - ERK1/2 - Rhodiola (Crassulaceae)

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