Planta Med 2009; 75(13): 1415-1417
DOI: 10.1055/s-0029-1185773
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Mangiferin Inhibits Passive Cutaneous Anaphylaxis Reaction and Pruritus in Mice

Bomi Lee1 , Hien Trung Trinh1 , Eun-Ah Bae1 , Kangshik Jung1 , Dong-Hyun Kim1
  • 1Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University Dongdaemun-ku, Seoul, Korea
Further Information

Publication History

received February 18, 2009 revised April 24, 2009

accepted April 28, 2009

Publication Date:
16 June 2009 (online)

Abstract

The antiallergic effect of mangiferin isolated from the rhizome of Anemarrhena asphodeloides Bunge (family Liliaceae) was measured in vitro and in vivo. Orally and intraperitoneally administered mangiferin potently inhibited passive cutaneous anaphylaxis (PCA) reaction induced by IgE-antigen complex as well as pruritus induced by compound 48/80 in mice. Mangiferin also inhibited the expression of the proinflammatory cytokine TNF-α and the IgE-switching cytokine IL-4 as well as transcription factor NF-κB activation in RBL-2H3 cells stimulated by IgE-antigen complex. These findings suggest that mangiferin may improve PCA reaction and pruritus.

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Prof. Dr. Dong-Hyun Kim

College of Pharmacy
Kyung-Hee University

1 Hoegi

Dongdaemun-ku

Seoul 130–701

Korea

Fax: + 82 29 57 50 30

Email: dhkim@khu.ac.kr