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DOI: 10.1055/s-0029-1185944
© Georg Thieme Verlag KG Stuttgart · New York
Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro
Publication History
received April 9, 2009
revised June 11, 2009
accepted June 13, 2009
Publication Date:
27 July 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/201001/lookinside/thumbnails/10.1055-s-0029-1185944-1.jpg)
Abstract
Glucose uptake assay-guided fractionations on the methanol extract of Sophorae Flos led to the isolation of the flavonoids rutin (1), narcissin (2), quercetin (3), tamarixetin (4), and kaempferol (5) and the isoflavonoids cajanin (6), genistein (7), orobol (8), and pratensein (9). Among them, 1, 4, 5, 6, 8, and 9 significantly improved basal glucose uptake in HepG2 cells. Their improving effects were concentration dependent. Compounds 4, 5, 6, and 9 exhibited effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. However, 2, 3, and 7 did not show any improving effects. Stimulating glucose uptake into peripheral cells may be responsible for reducing the level of blood glucose in the circulation. Therefore, these findings demonstrate a potential to develop these flavonoids and isoflavonoids as hypoglycemic drugs.
Key words
Sophora japonica - Leguminosae - flavonoids - isoflavonoids - glucose uptake - diabetes mellitus
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