Planta Medica, Table of Contents Planta Med 2010; 76(2): 146-151DOI: 10.1055/s-0029-1186031 Natural Product ChemistryOriginal Papers© Georg Thieme Verlag KG Stuttgart · New YorkNew Carvotanacetone Derivatives from Sphaeranthus africanus Consolacion Y. Ragasa1 , Po-Wei Tsai1 , Cecilia T. Galvez2 , Chien-Chang Shen3 1Chemistry Department, De La Salle University and Center for Natural Sciences and Ecological Research, De La Salle University, Manila, Phillipines 2Department of Biological Sciences, Central Luzon State University, Munoz Science City, Nueva Ecija, Philippines 3National Research Institute of Chinese Medicine, Taipei, Taiwan Recommend Article Abstract Buy Article(opens in new window) Abstract The dichloromethane extract of the air-dried leaves of Sphaeranthus africanus afforded four new carvotanacetone derivatives (1, 2, 3a, and 3b). Their structures were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1–3 exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Trichophyton mentagrophytes and Aspergillus niger. Key words Sphaeranthus africanus - Asteraceae - carvotanacetone derivatives - antimicrobial Full Text References References 1 Quisumbing E. Medicinal plants of the Philippines. Manila; Bureau of Printing 1978: 998-999 2 Ahmed A A, Mahmoud A A. Carvotanacetone derivatives from the Egyptian plant Sphaeranthus suaveolens. . Phytochemistry. 1997; 45 533-535 3 Jacupovic J, Grenz M, Bohlman F, Mungai G M. Carvotanacetone derivatives and eudesman-12,6β-olides from Sphaeranthus species. Phytochemistry. 1990; 29 1213-1217 4 Zdero C, Bohlmann F, Mungai G M. Carvotanacetone derivatives and other constituents from representatives of the Sphaeranthus group. Phytochemistry. 1991; 30 3297-3303 5 Guevara B Q, Recio B V. Phytochemical, microbiological and pharmacological screening of medicinal plants. Manila; Acta Manilana Supplements, UST Research Center 1985: 45-50 Prof. Dr. Consolacion Y. Ragasa Chemistry Department and Center for Natural Sciences and Ecological ResearchDe La Salle University 2401 Taft Avenue 1004 Manila Phillipines Phone: + 63 25 36 02 30 Email: ragasac@dlsu.edu.ph
