A Phenylpropanoid, a Slovenolide, Two Sulphur-Containing Germacranes and Ca²⁺-ATPase Inhibitors from Thapsia villosa

Abstract

A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca²⁺-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca²⁺]_c) in human platelets in a concentration-dependent manner.

Key words

Thapsia villosa - Apiaceae - germacranes - phenylpropanoids - slovenolides - thapsigargins - transtaganolides - Ca²⁺‐ATPase inhibitors

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