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DOI: 10.1055/s-0029-1186193
© Georg Thieme Verlag KG Stuttgart · New York
Anti-HIV‐1 and Anti-Inflammatory Lupanes from the Leaves, Twigs, and Resin of Garcinia hanburyi
Publication History
received July 10, 2009
revised September 10, 2009
accepted September 14, 2009
Publication Date:
14 October 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/201004/lookinside/thumbnails/10.1055-s-0029-1186193-1.jpg)
Abstract
Two new lupanes, 2α-acetoxy-3β-hydroxy-19β-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2α-hydroxy-3β-acetoxy-19β-hydrogen-lup-20(29)-en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O-β-D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 1–3 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (1–4) displayed anti-HIV‐1 activities in the anti-HIV‐1 reverse transcriptase (IC50 values 16.3–116.9 µg/mL) and syncytium assays (EC50 5.6–73.6 µg/mL, SI 1.7–3.3). Moreover compounds 1–4 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model.
Key words
Garcinia hanburyi - Guttiferae - lupanes - anti‐HIV‐1 - anti‐inflammatory
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Prof. Vichai Reutrakul
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Faculty of Science
Mahidol University
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