Terpene Glycosides and Cytotoxic Constituents from the Seeds of Amomum xanthioides

Abstract

Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1S,4S,5S)-5-exo-hydroxycamphor 5-O-β-D-glucopyranoside (2) and (1R,4R,5S)-5-endo-hydroxycamphor 5-O-β-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1S,4R,6R)-(+)-6-endo-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a sulforhodamine B bioassay.

Key words

Amomum xanthioides - Zingiberaceae - diterpene glycoside - monoterpene glycoside - cytotoxicity

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