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Eur J Pediatr Surg 2009; 19(4): 211-215
DOI: 10.1055/s-0029-1202250
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Reduction of Postoperative Adhesions by Perfluorocarbons: An Experimental Study in a Rat Model

P. Degenhardt1 , M. Pelzer1 , B. Fischer1 , S. Kraft2 , N. Sarioglu3 , H. Mau1 , M. Rüdiger4
  • 1Klinik und Poliklinik für Kinderchirurgie, Universitätsmedizin Berlin, Charite, Berlin, Germany
  • 2Klinik und Poliklinik für Kinderchirurgie, Mutterhaus der Borromäerinnen, Trier, Germany
  • 3Klinik für Paidopathologie, Universitätsmedizin Berlin, Charite, Berlin, Germany
  • 4Klinik und Poliklinik für Kinder- und Jugendmedizin, Medizinische Fakultät Carl Gustav Carus, Dresden, Germany
Further Information

Publication History

received August 31, 2008

accepted after revision January 6, 2009

Publication Date:
23 June 2009 (online)

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Abstract

Peritoneal adhesions are a well-known and frequently occurring postoperative complication. Many published studies have looked into the prophylaxis of adhesions following abdominal surgery, but only few clinically relevant agents have been reported. Most publications refer to adult patients and not to paediatric patient collectives. This experimental study in a rat model compares the effect of perfluorocarbons as adhesion prophylaxis with those of a well-known anti-adhesive agent Adept® and with an untreated control group. We hypothesized that PFC might have a double effect: initially it could suppress the accumulation of monocytes and neutrophilic granulocytes, and subsequently it would work as a barrier to prevent contact between the visceral and parietal layers of the peritoneum. After a standardised operation, PFC was injected into the abdominal cavity of rats in the study group. Macroscopically, the PFC group did not fare significantly better, but nevertheless a clear tendency towards fewer adhesions after the application of PFC could be ascertained.

Key words

peritoneal adhesions - experimental study in a rat model - perfluorocarbons (PFC, FC-77)

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Correspondence

P. Degenhardt

Klinik und Poliklinik für Kinderchirurgie

Universitätsmedizin Berlin

Charite

Augustenburger Platz 1

13353 Berlin

Germany

Phone: +49/30/450 56 61 62

Fax: +49/30/450 56 69 05

Email: petra.degenhardt@charite.de