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Exp Clin Endocrinol Diabetes 2010; 118(3): 167-171
DOI: 10.1055/s-0029-1202774
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Improvement of the Metabolic Syndrome and of Non-alcoholic Liver Steatosis upon Treatment of Hypogonadal Elderly Men with Parenteral Testosterone Undecanoate

A. Haider 1 , L. J. G. Gooren 2 , P. Padungtod 3 , F. Saad 4
  • 1Private urology praxis, Bremerhaven, Germany
  • 2Endocrinology, VUmc, Amsterdam, The Netherlands
  • 3Faculty of Veterinary Medicine, Chiang Mai University, Thailand
  • 4Bayer Schering Pharma, Scientific Affairs Men's Healthcare, Berlin, Germany and Gulf Medical University School of Medicine, Ajman, UAE
Further Information

Publication History

received 18.10.2008 first decision 17.02.2009

accepted 17.02.2009

Publication Date:
26 May 2009 (online)

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Abstract

This is a study of a cohort of 117 men aged between 34–69 years, with plasma testosterone levels between 5.9–12.1 nmol/L (N>14.0 nmol/L) who were treated with administration of testosterone undecanoate for 1 year as the sole intervention. There was a remarkable improvement of body weight, BMI and waist size along with an improvement of lipid profiles. Liver fat is highly significantly and linearly correlated with all components of the metabolic syndrome. Hepatic inflammation secondary to liver steatosis is a potential contributor to the low-grade inflammation associated with the metabolic syndrome. Elevations of liver enzymes are associated with higher CRP concentrations. Levels of ALT (GPT) AST (GOT) and CRP had decreased significantly after one year of testosterone treatment. At baseline 74/117 met the criteria of the metabolic syndrome as defined by the NCEP and after one year of testosterone treatment this number had declined to 42/117.

Key words

testosterone - metabolic syndrome - liver steatosis - aging

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Correspondence

Prof. F. Saad

BU Primary Care/Men's Healthcare

Scientific Affairs

c/o Bayer Schering Pharma AG

13342 Berlin

Geb. S101, 09, 226

Phone: +49/30/468 150 57

Phone: +49/0/151/1671 54 28

Fax: +49/30/468 950 57

Email: Farid.Saad@bayerhealthcare.com