RSS-Feed abonnieren
DOI: 10.1055/s-0029-1202796
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Activation of α1-adrenoceptors Inhibits Growth Hormone Secretion in Humans
Publikationsverlauf
received 10.04.2008
first decision 20.08.2008
accepted 19.11.2008
Publikationsdatum:
16. April 2009 (online)

Abstract
In order to determine whether an α1-adrenergic mechanism is involved in the secretion of Growth Hormone (GH) in humans, we studied the effect of the α1-adrenergic-stimulating agent methoxamine on serum GH levels in twelve normal males (age range 22–32 years). Intravenous infusion of methoxamine (dose: 6 μg/kg/min; duration: 150 min) significantly reduced serum GH levels at time 120 and 150, and on integrated concentrations. These data suggest that α1-adrenergic receptors inhibit tonic GH secretion in humans.
Key words
α1-adrenoceptors - growth hormone - humans - hypothalamus - methoxamine
References
- 1 al-Damluji S. Adrenergic control of the secretion of anterior pituitary hormones. Baillieres Clin Endocrinol Metab. 1993; 7 355-392
- 2 al-Damluji S, Francis D. Activation of central alpha 1-adrenoceptors in humans stimulates secretion of prolactin and TSH, as well as ACTH. Am J Physiol. 1993; 264 E208-214
- 3 Cella SG, Morgese M, Mantegazza P. et al . Inhibitory action of the alpha 1-adrenergic receptor on growth hormone secretion in the dog. Endocrinology. 1984; 114 2406-2408
- 4 Cella SG, Locatelli V, Gennaro V De. et al . Pharmacological manipulations of alpha-adrenoceptors in the infant rat and effects on growth hormone secretion. Study of the underlying mechanisms of action. Endocrinology. 1987; 120 1639-1643
- 5 De Souza EB, Kuyatt BL. Alpha 1-adrenergic receptors in the neural lobe of the rat pituitary: autoradiographic identification and localization. Endocrinology. 1987; 120 2227-2233
- 6 Delitala G, Palermo M, Tomasi P. et al . Adrenergic stimulation of the human pituitary-adrenal axis is attenuated by an analog of met-enkephalin. Neuroendocrinology. 1991; 53 41-46
- 7 Delitala G, Trainer PJ, Oliva O. et al . Opioid peptide and alpha-adrenoceptor pathways in the regulation of the pituitary-adrenal axis in man. J Endocrinol. 1994; 141 163-168
- 8 Leibowitz SF, Jhanwar-Uniyal M, Dvorkin B. et al . Distribution of alpha-adrenergic, beta-adrenergic and dopaminergic receptors in discrete hypothalamic areas of rat. Brain Res. 1982; 233 97-114
- 9 Mazza E, Ghigo E, Bellone J. et al . Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man. Endocrinol Exp. 1990; 24 211-219
- 10 Mounier F, Bluet-Pajot MT, Durand D. et al . Alpha-1-noradrenergic inhibition of growth hormone secretion is mediated through the paraventricular hypothalamic nucleus in male rats. Neuroendocrinology. 1994; 59 29-34
- 11 Wilcox BJ, Raskind MA, Ko GN. et al . Localization of 3H-prazosin binding sites in the supraoptic and paraventricular nuclei of the human hypothalamus. Neuroendocrinology. 1990; 51 315-319
Correspondence
G. FanciulliMD
Istituto di Clinica Medica
University of Sassari
Viale San Pietro 8
07100 Sassari
Italy
Telefon: +39/079/22 90 19
Fax: +39/02/700 532 950
eMail: gfanciu@uniss.it