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Semin Respir Crit Care Med 2009; 30(2): 161-171
DOI: 10.1055/s-0029-1202935
© Thieme Medical Publishers

New Antimicrobial Molecules and New Antibiotic Strategies

Felipe Rodríguez de Castro1 , Olga Rajas Naranjo3 , Javier Aspa Marco3 , Jordi Solé Violán2
  • 1Servicio de Neumología, Hospital Universitario de Gran Canaria “Dr. Negrín,” Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain
  • 2Servicio de Medicina Intensiva, Hospital Universitario de Gran Canaria “Dr. Negrín,” Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas, Spain
  • 3Servicio de Neumología, Hospital Universitario de La Princesa, Madrid, Spain
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Publication History

Publication Date:
18 March 2009 (online)

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ABSTRACT

Drug options for treatment of infections are increasingly limited. The pharmaceutical industry has found it difficult to discover new antimicrobial agents, and only two novel classes of antibiotics, the oxazolidinones and the cyclic lipopeptides, have entered the market since the late 1960s. Few new agents have reached the market in the last decade with potential interest for community-acquired pneumonia (CAP) treatment, including linezolid (the first oxazolidinone in clinical use), new fluoroquinolones, cefditoren, ertapenem, and telithromycin. Agents currently in clinical development include other novel quinolones and ketolides, broad-spectrum cephalosporin derivatives, faropenem, several glycopeptides, and iclaprim. Other molecules are considered to be promising candidates for the future. In addition to the foregoing agents, alternative treatment approaches have also been introduced into clinical practice, which include the administration of the appropriate antimicrobials in a timely manner and the consideration of the pharmacokinetic–pharmacodynamic properties of the agent(s).

KEYWORDS

Antibiotics - new antimicrobials - community-acquired pneumonia - resistance - treatment options

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Felipe Rodríguez de CastroPh.D. M.D. 

Servicio de Neumología, Hospital Universitario de Gran Canaria “Dr. Negrín,” Universidad de Las Palmas de Gran Canaria (ULPGC)

Barranco de la Ballena, s/n, 35010 Las Palmas, Spain

Email: frodcasw@gobiernodecanarias.org