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Exp Clin Endocrinol Diabetes 1983; 81(1): 3-16
DOI: 10.1055/s-0029-1210201
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Steroid-Membrane-Adenylate Cyclase Interactions during Xenopus laevis Oocyte Meiosis Reinitiation: A New Mechanism of Steroid Hormone Action

E.-E. Baulieu
  • Unité de Recherches sur le Métabolisme Moléculaire et la Physio-Pathologie des Stéroides de l'Institut National de la Santé et de la Recherche Médicale (INSERM U33), Bicêtre/France
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1982

Publikationsdatum:
17. Juli 2009 (online)

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Summary

Progesterone acts physiologically on Xenopus laevis oocyte meiosis reinitiation in interacting with plasma membrane. Hormonal studies indicate a specific “receptor-like” structure. The involvement of membrane adenylate cyclase activity which is selectively decreased by progesterone is described in intact oocytes as well as in a cell-free membrane containing system. The participation of Ca2+ changes and of phospholipid components of membrane is analyzed. We discuss the possibility that the progesterone-oocyte system is a model for understanding other steroid hormone activities in other target cells.