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Exp Clin Endocrinol Diabetes 1983; 81(1): 94-97
DOI: 10.1055/s-0029-1210213
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Decrease of Glucose-Induced Insulin Secretion of Pancreatic Rat Islets after Irradiation in Vitro1)

Dagmar Heinzmann, R. Nadrowitz, W. Besch, W. Schmidt, H.-J. Hahn
  • Central Institute of Diabetes, Research and Treatment, Karlsburg (Head: OMR Prof. Dr. H. Bibergeil), and Radiological Clinic (Head: MR Prof. Dr. W. Schmidt), University of Greifswald/GDR
1) Investigations were carried out as a part of the “Hauptforschungsrichtung Diabetes mellitus und Fettstoffwechselstörungen”, supported by the Ministry of Health of the GDR.
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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

Irradiation of pancreatic rat islets up to a dose of 2.5 Gy did neither alter glucose nor IBMX-induced insulin secretion studied in vitro. The insulin as well as glucagon content of irradiated islets were similar as in the control tissue. This was also true in islets irradiated with 25 Gy which were characterized by a decreased insulin secretion in the presence of glucose and IBMX, respectively. Since we did not find indications of an enhanced hormone output in the radiation medium, we want to suggest that higher irradiation doses affect insulin release of pancreatic islets in vitro. This observation has to be taken into account for application of radioimmunosuppression for transplantation.