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Exp Clin Endocrinol Diabetes 1983; 82(4): 91-96
DOI: 10.1055/s-0029-1210260
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of Hypercalcaemia on Adrenocortical and Growth Hormone Secretion

I. Žofková, M. Neradilová, L. Stárka, I. Kimlová, A. Šimečková
  • Research Institute of Endocrinology, (Director: MUDr. J. Pečeny, CSc), Prague, and Chair of Nuclear Medicine (Director: Prof. MUDr. J. Prokopec, CSc), Faculty of Medicine and Hygiene, Charles University, Prague/Czechoslovakia
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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

The authors investigated in 19 healthy women changes in the plasma levels of cortisol and growth hormone during acute hypercalcaemia induced by a load of 8.9 mg Ca2+/kg body weight, administered as intravenous infusion and the effect of hypercalcaemia on the adrenocortical and somatotrophic secretory reserve assessed by the test with insulin hypoglycaemia.

Hypercalcaemia causes a rise of the basal cortisol plasma level starting at the 90 th minute from the onset of the infusion when the calcium level reaches values of 2.99 mmol/l. The adrenocortical secretory reserve is, however, significantly reduced by hypercalcaemia. Hypercalcaemia does not affect growth hormone levels nor the somatotrophic secretory reserve.