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Exp Clin Endocrinol Diabetes 1983; 82(4): 107-110
DOI: 10.1055/s-0029-1210264
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Impairment of Osmoregulation in the Rat Offsprings of Hyperadiuretic Mothers Is Probably of Renal Nature2)

B. Lichardus, A. Szabóová, O. Földes, J. Ponec, K. Horký1 , J. Šrámková1
  • 1Institute of Experimental Endocrinology, Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava and Laboratory for Endocrinology and Metabolism at the 3rd Clinic of Medicine, Faculty of Medicine, Charles University, Prague
  • Institute of Experimental Endocrinology, Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava and Laboratory for Endocrinology and Metabolism at the 3rd Clinic of Medicine, Faculty of Medicine, Charles University, Czechoslovakia
2) The results have been presented at a Symposium with International participation on “Peptides and Brain Function” in Łodz in 1979 (Lichardus et al., 1979) and at the XXVIII International Congress of Physiological Sciences, Budapest 1980 (Szabóová et al., 1980).
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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

Experimental hyperadiuretism in pregnant rats was induced by applying them daily throughout the pregnancy a synthetic analogue of vasopressin — dDAVP (1-deamino-8-D-arginine vasopressin). It brought about a moderate alteration in the ability to produce hypertonic urine in their offsprings. The osmoregulatory function in the offsprings in the course of fetal development could have been suppressed either by a direct or an indirect effect of dDAVP i.e. by the hypotonicity of mothers' internal environment. There is by now some evidence based on the simultaneous determination of urinary vasopressin and osmolality that the impairment of the osmoregulatory function may be, at least partly, on the renal level.