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Exp Clin Endocrinol Diabetes 1983; 82(4): 111-114
DOI: 10.1055/s-0029-1210265
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of Anti-Inflammatory Steroids on the Activity of Selected Lysosomal Hydrolases in Serum of Rats with Experimental Liver Fibrosis

M. Dróżdż, Krystyna Olczyk, E. Kucharz
  • Department of Medical Analytics and Clinical Chemistry (Head: Assoc. Prof. M. Dróżdż M.D.) Institute of Bioanalytics and Environmental Studies, Silesian School of Medicine, Sosnowiec/Poland
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Publikationsverlauf

1982

Publikationsdatum:
17. Juli 2009 (online)

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Summary

Liver fibrosis was produced in rats by subcutaneous injections of carbon tetrachloride.

The effect of anti-inflammatory steroids (hydrocortisone, prednisone, dexamethasone) on the activity of serum lysosomal hydrolases (β-N-acetylglucosaminidase, β-glucosidase and α-mannosidase) was investigated in healthy and CC14 poisoned rats.

The marked increase of enzymatic activity in blood serum was observed in animals with CC14-induced liver fibrosis. Quite opposite results were found in normal rats treated with glucoeorticosteroids.

In rats which were given both carbon tetrachloride and corticosteroids the obtained values of serum enzymatic activity did not have a uniform character as compared to controls or CCl4 intoxicated rats.

Presumable mechanisms of the results obtained are discussed.