Alpha-Adrenergic Effects on Insulin Release from Isolated Pancreatic Rat Islets Are Influenced by Alpha-Glucosidase

Cz. Wójcikowski; V. Maier; E. F. Pfeiffer

doi:10.1055/s-0029-1210358

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Exp Clin Endocrinol Diabetes 1984; 83(3): 370-372
DOI: 10.1055/s-0029-1210358

Short Communication

Alpha-Adrenergic Effects on Insulin Release from Isolated Pancreatic Rat Islets Are Influenced by Alpha-Glucosidase

Cz. Wójcikowski¹ , V. Maier² , E. F. Pfeiffer²

¹Laboratory of Endocrinology, Institute of Obstetrics and Gynecology, Medical Academy, Gdańsk/Poland
²Department of Internal Medicine I, University of Ulm/FRG

Further Information

Publication History

1982

1983

Publication Date:
17 July 2009 (online)

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Summary

The modification of isolated pancreatic rat islets by pretreatment with alpha-glucosidase abolished the stimulatory action of phentolamine but not changed glucose induced insulin release. In modified islets the inhibitory effect of epinephrine was only slightly changed. The data indicated that alpha-adrenergic receptors may be selectively damaged by alpha-glucosidase.

Key words

Insulin release - isolated islets - alpha-glucosidase