Augmentation of Mitogen-Induced Interferon Production in Lymphocytes by Thymosin

W. Diezel; Ellen Rentz; G. Ermolin; O. G. Sakandelidze; N. Sönnichsen

doi:10.1055/s-0029-1210372

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Exp Clin Endocrinol Diabetes 1984; 84(4): 99-104
DOI: 10.1055/s-0029-1210372

Original

Augmentation of Mitogen-Induced Interferon Production in Lymphocytes by Thymosin

W. Diezel¹ , Ellen Rentz² , G. Ermolin³ , O. G. Sakandelidze³ , N. Sönnichsen¹

¹Department of Dermatology (Charité), Humboldt University, Berlin
²Central Institute of Cancer Research, Academy of Sciences of the GDR, Berlin
³Allunion Center of Cardiology, Academy of Medical Science, Moscow

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Publikationsverlauf

1983

Publikationsdatum:
17. Juli 2009 (online)

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Summary

Thymosin (thymosin fraction 5), in combination with mitogen (concanavalin A) augments the amount of interferon produced in human peripheral blood lymphocytes (in vitro studies). In addition, after pretreatment of mice with thymosin (intraperitoneal administration), thymosin augments the mitogen-induced interferon production in mouse lymphocytes in vitro. The produced interferon is immune interferon (IFN-γ) as determined by sensitivity to pH 2 and lack of neutralization by antibodies to IFN-α or IFN-β. Results indicate that thymic hormones may also participate in the regulation of interferon production.

Key words

Interferon - concanavalin A - thymosin - mouse