Download PDF
Exp Clin Endocrinol Diabetes 1984; 84(6): 294-298
DOI: 10.1055/s-0029-1210401
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Hypercalcaemia and Calcitonin Inhibit Prolactin Secretion

I. Žofková, J. Nedvídková
  • Research Institute of Endocrinology (Director: MUDr. RNDr. L. Stárka, DrSc), Prague/Czechoslovakia
Further Information

Publication History

1984

Publication Date:
17 July 2009 (online)

Also available at
 PDF Download  Permissions and Reprints

Summary

The authors investigated the effect of acute hypercalcaemia induced by a 2-hour intravenous infusion of calcium gluconate (8.9 mg Ca2+/kg b. w.) on the lactotrophic secretory reserve assessed by the test with insulin hypoglycaemia (Δ PRL) and the effect of an intravenous bolus of 50 IU synthetic salmon calcitonin on the lactotrophic secretory reserve assessed by means of the TRH test (Δ PRL). Acute hypercalcaemia inhibits PRL levels stimulated by insulin hypoglycaemia (p > 0.01) as well as Δ PRL (p > 0.01). Calcitonin reduces PRL levels at rest and TRH stimulated levels (p > 0.05 and p > 0.01, respectively) as well as Δ PRL (p > 0.01). The prolactin inhibiting effect of calcitonin resembles markedly the effect of hypercalcaemia. The exact mechanism of these changes and the physiological impact of calcitonin on the regulation of PRL secretion is not known.

Key words

Hypercalcaemia - calcitonin - prolactin