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Exp Clin Endocrinol Diabetes 1985; 85(1): 70-74
DOI: 10.1055/s-0029-1210421
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Frequency of Islet Cell Surface Antibodies and Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) of Mononuclear Cells in HLA-Typed Patients with High Diabetes Risk*

Ilona Rjasanowski, D. Michaelis, H. Dietz, Sabine Witt, Erika Köhler, S. Knospe
  • Central Institute of Diabetes “Gerhardt Katsch” (Director: OMR Prof. Dr. sc. med. H. Bibergeil) Karlsburg/GDR
* Dedicated to OMR Prof. Dr. sc. med. H. Bibergeil on the occasion of his 60th birthday.
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1984

Publikationsdatum:
16. Juli 2009 (online)

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Summary

To evaluate the significance of ICSA as a prognostic marker for the development of type I diabetes we investigated 66 subjects with first degree relatives of type I (47) and type II (9) diabetes as well as subjects with anamnestical data suggestive of diabetes- Patients were studied for glucose tolerance (oGTT) and IRI-response, ICSA (indirect fluorescence of living rat islet cell suspensions), ADCC (specific 51Cr-release of serum pretreated neonatal rat islets elicited by mono-nuclear cells) and HLA-antigens. 23 subjects revealed normal glucose tolerance, 17 impaired glucose tolerance and 26 had a prevoius abnormality. The incidence of ICSA varied between 46 and 53 per cent, that of positive ADCC between 22 and 56 per cent, both being highest in subjects with IGT. 87 per cent of all patients revealed diabetes associated HLA-antigens. We found no correlation of ICSA with glucose tolerance, IRI-response, ADCC and HLA-antigens. In conclusion it can be said that ICSA are present in a high percentage in patients with high diabetes risk but their predictive role as a marker for the manifestation must be elucidated in follow-up studies.

Key words

ICSA - ADCC - HLA - Glucose tolerance - Prognostic marker