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Exp Clin Endocrinol Diabetes 1985; 85(2): 204-208
DOI: 10.1055/s-0029-1210437
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Dehydroepiandrosterone Sulphate Loading Test and Determination of Plasma Oestetrol Concentration in Late Pregnancy

K. Schollberg1 , Erika Seiler1 , S. Wagner2
  • 1Institute for Clinical Chemistry and Laboratory Diagnostic,(Director: MR Prof. Dr. sc. med. W. Jaross) Medical Academy “Carl Gustav Carus” Dresden/GDR
  • 2Department of Obstetrics and Gynaecology) (Director: OMR Prof. Dr. sc. med. B. Sarembe), Medical Academy “Carl Gustav Carus” Dresden/GDR
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Publikationsverlauf

1984

Publikationsdatum:
16. Juli 2009 (online)

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Summary

Intravenous application of dehydroepiandrosterone sulphate (DHEA-S) was performed in 6 women with normal progress of pregnancy, 3 pregnant women with multiple pregnancy and 4 pregnants with intrauterine death of the foetus (32ndto 38thweak). The oestetrol concentrations in blood serum were estimated during 5 h after the injection. In most cases an increase could be observed, but this was inhomogenous. The oestetrol concentration even rises in cases of intrauterine death of the foetus. In 7 cases of uncomplicated pregnancies the DHEA-S loading test was done within 2 to 6 h before delivery. The oestetrol concentration in the cord serum of the newborns was not higher than in controls without DHEA-S application, whereas oestradiol in maternal serum showed the expected rise.

We conclude that the determination of oestetrol after DHEA-S loading can not be used for the jugdgement of the foetal situation.

Key words

Dehydroepiandrosterone sulphate loading test - Plasma oestetrol - Foetoplacental unit - Steroid metabolism