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Exp Clin Endocrinol Diabetes 1985; 85(2): 209-216
DOI: 10.1055/s-0029-1210438
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Relationship between Serum Dehydroepiandrosterone Sulphate and Urinary 17-Ketosteroid Values

T. Fehér, E. Poteczin1 , L. Bodrogi
  • First Department of Medicine, Semmelweis University Medical School (Head: Prof. Dr. I. Hollo), Budapest/Hungary
  • 1Department of Obstetrics and Gynaecology, Robert Hospital (Head: Dr. I. Kiss), Budapest/Hungary
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

To assess the validity of serum dehydroepiandrosterone sulphate (DS) radioimmunoassay instead of urinary total 17-ketosteroid (17-KS) or individual metabolite (dehydroepiandrosterone + etiocholanolone + androsterone ; D + E + A) determination to control adrenal androgen function, a comparative study has been performed. Mathematical analysis of simultaneous estimates revealed significant correlation when normal or above normal 17-KS or D + E + A excretion relative to serum DS were considered. Poor correlation was observed when below normal metabolite excretion and serum DS were related. Furthermore, there was a significant correlation between estimates of 17-KS (or D + E + A) and those of serum unconjugated D also determined by radioimmunoassay. The serum DS radioimmunoassay appeared to be a reliable tool to assess adrenal androgen function, at least in patients exhibiting normal or high 17-ketosteroid values

Key words

Dehydroepiandrosterone - 17-Ketosteroids - Radioimmunoassay