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Exp Clin Endocrinol Diabetes 1985; 86(4): 53-60
DOI: 10.1055/s-0029-1210472
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Insulin Binding on Erythrocytes in Unsatisfactorily Controlled Obese Diabetics (Type 2) and Nonobese Diabetics (Type 1)

J. Páv, J. Hilgertová, J. Šrámková
  • 3rd Medical Clinic (Head Prof. Dr. med. V. Pacovský, DrSc.), Faculty of General Medicine, Charles University, Prague/Czechoslovakia
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Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

Insulin binding to receptors on erythrocytes was studied in 2 groups of poorly controlled diabetics, i.e. a) 9 noninsulin dependent obese diabetics, b) 8 insulin-dependent nonobese diabetics, and in a group of 10 nondiabetic control subjects. The mean binding value in obese diabetics-type 2 was significantly lower than in controls (4.5 ± 0.4% vers. 7.3 ± 0.4%), the difference between the control mean value and the mean value in diabetics-type 1 (6.3 ± 0.8%) was not statistically significant. Compared with the controls, lower numbers of insulin receptors per cell were found in both groups of diabetics (162 ± 9 vers. 60 ± 13 and 88 ± 13, resp.). The lower number of receptors in diabetics-type 1 seems to be counterbalanced, at least partly, by their higher affinity.

Key words

Diabetes mellitus - Insulin receptors - Erythrocytes