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Exp Clin Endocrinol Diabetes 1985; 86(5): 197-206
DOI: 10.1055/s-0029-1210487
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Basal Prolactin and the Behaviour of the Gonadotrophins, Testosterone, Androstenedione, Estradiol, and the Sex-Hormone-Binding Globulin during Stimulation with Clomiphene in Subjects with Spermatogenic Disorders

P. Bolufer, A. Rodriguez, P. Antonio, E. Bosch, T. Peiró
  • Department of Clinical Pathology (Head: Dr. J. Aznar) and, Obstetrics and Gynecology (Head: Prof. Dr. M. Galbis), Ciudad Sanitaria “La Fé”, Valencia/Spain
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Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

To clarify the significance of clomiphene test in spermatogenic disorders, it was performed on three groups of subjects: 10 with normozoospermia, 29 with oligozoospermia, and 11 with azoospermia. Two basal blood samples were drawn five days apart; prolactin, FSH, LH, estradiol, testosterone, androstenedione and sex-hormone-binding globulin were determined. 100 mg of clomiphene per day were administered for eleven consecutive days; another sample was drawn on the eleventh day and all the basal parameters, except prolactin, were determined. It may be concluded from the results: a) All the parameters studied increased significantly after clomiphene; and b) Testosterone levels obtained after clomiphene, as well as the increases in this hormone during the test and the ratio ΔT/ΔLH, were significantly lower in the oligozoospermic group. This finding suggests a decrease in the testicular androgenic function of this group.

Key words

Spermatogenic disorders - Clomiphene test - Hormones