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Exp Clin Endocrinol Diabetes 1985; 86(5): 237-240
DOI: 10.1055/s-0029-1210492
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Interactions between Progestins and Estradiol on Serum Lipids in the Rat 1)

R. Tkocz, G. Schmidt, H. G. Hillesheim
  • Academy of Sciences of the GDR, Central Institute of Microbiology and Experimental Therapy (Director: Prof. Dr. F. Bergter), Jena/GDR
1) Presented at the 3rd Symposium on Biochemical Aspects of Steroid Research, October 1—6, 1984, Weimar/GDR
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

In female rats the influence of progestins of the estrane type [norethisterone acetate (NEA), norgestrel (NG) and dienogest (DEG)] and of the pregnane type [chlormadinone acetate (CMA), progesterone (P)] on total cholesterol (TC) and high-density-lipoprotein cholesterol (HDL-C) in serum has been investigated in combination with estradiol (E). E increased TC (45%) and HDL-C (12%). NEA, NG and DEG alone decreased TC maximally by 58% and HDL-C maximally by 67%, CMA and P were without influence. In combination with E, the gestagens NEA, NG and DEG suppressed the E-induced increase of TC and HDL-C, whereas CMA and P did not counteract the TC increase. The effects of estrogen/gestagen combinations on HDL-C in the serum of rats are similar to those in men, but species differences in the lipoprotein metabolism must be taken into consideration.

Key words

Progestins - Estradiol - Lipoproteins