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Exp Clin Endocrinol Diabetes 1986; 87(2): 118-124
DOI: 10.1055/s-0029-1210532
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Model Systems for Pharmacokinetics of Steroid Drugs Subject to Enterohepatic Circulation1)

W. Schumann, H. G. Hillesheim, G. Gira
  • Central Institute of Microbiology and Experimental Therapy (CIMET), (Director: Prof. Dr. F. Bergter), Department of Steroidbiochemistry (Head: Prof. Dr. K. Schubert), Department of Pharmacology and Toxicology (Head: Prof. Dr. H. Hoffmann) and Department of Biophysics (Head: Dr. W. Knorre), Jena/GDR
1) Presented at the 3rd Symposium on Biochemical Aspects of Steroid Research, October 1—6, 1984, Weimar/GDR
Further Information

Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

A number of drugs including steroid hormones undergo enterohepatic circulation (EHC) which influences the drug disposition parameters. EHC of drugs leads to prolonged drug exposition which may enhance the risk of liver incompatibility. The extent of EHC expressed by the reabsorption rate of a given drug is of interest from the clinical and toxicological point of view.

A two-compartment model with an additional time lag was realized by a hybrid computer system to study the influence of EHC on the shape of plasma concentration-time profiles and pharmacokinetic parameters.

Reabsorption rates of potential steroid drugs were calculated by model-simulation and the results compared with the experimentally found ones.

Although the lag time model is only a simplified approximation to the underlying physiological processes it reflects sufficiently the pharmacokinetic profile of steroid drugs subject to EHC.

Key words

Computer models - Enterohepatic steroid circulation