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Exp Clin Endocrinol Diabetes 1986; 87(2): 201-207
DOI: 10.1055/s-0029-1210544
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Glycogenolytic Effect of Cortisol Previous to Its Interaction with the Cell Nucleus in Mouse Liver

A. Vallejo1) , M. Trueba, M. J. Sancho, M. Egaña, A. Marino, J. M. Macarulla
  • Departamento de Bioquímica, Facultad de Ciencias, Universidad del País Vasco, Bilbao/Spain
1) Recipient of a doctoral fellowship from the “Diputación Foral del Señorio de Vizcaya” , Bilbao, Spain
Further Information

Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

Activities of hepatic glycogen synthase a and glycogen phosphorylase a have been studied in mouse liver at different times after an acute intraperitoneal administration of hydrocortisone. It has been observed an increase of glycogen synthase a activity and a decrease of glycogen phosphorylase a between 2 and 3.5 hours after Cortisol injection. An-early effect, previous to the synthase activation has been discovered. Cortisol caused an increase of glycogen phosphorylase a activity in mice 45 min after injection. This early effect of Cortisol is independent of protein synthesis and it does not imply an increase in cAMP levels.

Key words

Cortisol - Glycogen phosphorylase - Glycogen synthase - cAMP-Mouse liver - Fasting