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Exp Clin Endocrinol Diabetes 1987; 89(2): 225-228
DOI: 10.1055/s-0029-1210641
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

A Factor in the Serum of Diabetic Patients Inhibits Microtubule Formation

I. F. Casson1 , S. J. Beahon2 , W. G. McLean2
  • 1The Royal Liverpool Hospital, University of Liverpool/Great Britain
  • 2The Department of Pharmacology and Therapeutics, University of Liverpool/Great Britain
Further Information

Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

The effect of serum from non-diabetic patients, diabetics without neuropathy and diabetics with significant neuropathy on the ability of pig brain microtubule proteins to polymerise in vitro to microtubules was observed. The extent of polymerisation on the second and third cycles of polymerisation was significantly reduced in the presence of diabetics' serum compared with non-diabetics' serum. No significant difference between the serum samples from diabetics with and without neuropathy could be found. The finding suggests the presence of a factor in the serum of diabetics, whether or not they have neuropathy, which will impair microtubule formation in vitro.

Key words

Diabetic complications - Tubulin - Albumin