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Exp Clin Endocrinol Diabetes 1988; 91(3): 282-286
DOI: 10.1055/s-0029-1210760
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Effect of Maturation on Insulin Secretion after Starvation in Isolated Perfused Rat Pancreas

T. Ikeda, T. Hoshino, M. Honda, T. Takeuchi, Y. Ito, O. Mokuda, M. Tominaga, H. Mashiba
  • First Department of Internal Medicine, Tottori University School of Medicine, Yonago / Japan
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1987

Publikationsdatum:
16. Juli 2009 (online)

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Summary

To determine the effect of maturation on glucose-induced insulin release after starvation, we investigated the insulin release from perfused pancreas of young adult rats after fasting for 18—20 hr. In the rats weighing 300—400 g (12—14 w) and 200—250 g (7—8 w), the glucose-induced insulin secretion from perfused pancreas of starved rats was similar to that of fed rats. While, in the rats weighing 100—150 g (4—5 w), both the first and the second phase of glucose-induced insulin secretion from perfused pancreas of starved rats was markedly decreased compared with that of fed rats.

These results suggest that insulin response to glucose is not matured in young adult rats weighing below 150 g (5 w).

Key words

Insulin secretion - Starvation - Perfused rat pancreas